# uniprot
## UniProt Queries
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source
### get_uniprot_seq
``` python
def get_uniprot_seq(
uniprot_id:str
)->str:
```
*Queries the UniProt database to retrieve the protein sequence for a
given UniProt ID.*
``` python
get_uniprot_seq("P04626")[:60]
```
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source
### get_uniprot_features
``` python
def get_uniprot_features(
uniprot_id:str
)->dict:
```
*Given a UniProt ID, fetch the protein metadata and annotated features.*
``` python
get_uniprot_features("P04626").keys()
```
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source
### get_uniprot_kd
``` python
def get_uniprot_kd(
uniprot_id:str
)->list:
```
*Query Domain: Protein kinase entries based on a UniProt ID.*
``` python
get_uniprot_kd("P04626")
```
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source
### get_uniprot_type
``` python
def get_uniprot_type(
uniprot_id:str, # UniProt accession to inspect
type_:str='Signal', # feature type to filter for
)->list[dict[str, object]] | list[str]:
```
*Get region sequences for a UniProt feature type.*
``` python
get_uniprot_type("P04626", "Signal")[:1]
```
## Sequence Mutation
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### apply_mut_single
``` python
def apply_mut_single(
seq:str, # protein sequence to edit
mutations:str, # point mutations such as E709A
start_pos:int=1, # residue number of seq[0]
)->str:
```
*Apply point mutations to a protein sequence.*
``` python
apply_mut_single("MEEPQ", "M1A", "E2S")
```
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source
### apply_mut_complex
``` python
def apply_mut_complex(
seq:str, # protein sequence to edit
mut:str, # composite mutation such as G776delinsVC/S783C
start_pos:int=1, # residue number of seq[0]
)->str:
```
*Apply a composite mutation string to a protein sequence.*
``` python
her2_seq = "LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFV"
apply_mut_complex(her2_seq, "G776delinsVC/S783C", start_pos=720)[:25]
```
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source
### compare_seq
``` python
def compare_seq(
seq1:str, # reference sequence
seq2:str, # sequence to compare against seq1
start_pos:int=1, # residue number of seq1[0]
label1:str='Original', # label for the first sequence block
label2:str='Mutant', # label for the second sequence block
visualize:bool=True, # include block alignment output when True
return_text:bool=False, # return the rendered text instead of None
)->str | None:
```
*Align two protein sequences and summarize the differences.*
``` python
print(compare_seq("MEEPQ", "MAEPQ", return_text=True))
```