import pandas as pd, seaborn as sns
from katlas.imports import *
from sklearn.preprocessing import StandardScaler
from matplotlib import pyplot as plt
from sklearn import set_config
set_config(transform_output = "pandas")Kinase embeddings
Prepare protein sequence embeddings and preprocess target values
Setup
Preprocess target
We will standardize each kinase’s PSSMs individually, so that each PSSM will have a mean of 0.
# load target
target = pd.read_csv('train_data/combine_freq_PSPA.csv').set_index('kinase')# standardize 0s,0t,0y
v0 = StandardScaler().fit_transform(target.iloc[:,-3:].T).T
# standardize all other positions
vv = StandardScaler().fit_transform(target.iloc[:,:-3].T).T
# combine the two
v = pd.concat([vv,v0],axis=1)v| -5P | -5G | -5A | -5C | -5S | -5T | -5V | -5I | -5L | -5M | -5F | -5Y | -5W | -5H | -5K | -5R | -5Q | -5N | -5D | -5E | -5s | -5t | -5y | -4P | -4G | -4A | -4C | -4S | -4T | -4V | -4I | -4L | -4M | -4F | -4Y | -4W | -4H | -4K | -4R | -4Q | -4N | -4D | -4E | -4s | -4t | -4y | -3P | -3G | -3A | -3C | -3S | -3T | -3V | -3I | -3L | -3M | -3F | -3Y | -3W | -3H | -3K | -3R | -3Q | -3N | -3D | -3E | -3s | -3t | -3y | -2P | -2G | -2A | -2C | -2S | -2T | -2V | -2I | -2L | -2M | -2F | -2Y | -2W | -2H | -2K | -2R | -2Q | -2N | -2D | -2E | -2s | -2t | -2y | -1P | -1G | -1A | -1C | -1S | -1T | -1V | -1I | -1L | -1M | -1F | -1Y | -1W | -1H | -1K | -1R | -1Q | -1N | -1D | -1E | -1s | -1t | -1y | 1P | 1G | 1A | 1C | 1S | 1T | 1V | 1I | 1L | 1M | 1F | 1Y | 1W | 1H | 1K | 1R | 1Q | 1N | 1D | 1E | 1s | 1t | 1y | 2P | 2G | 2A | 2C | 2S | 2T | 2V | 2I | 2L | 2M | 2F | 2Y | 2W | 2H | 2K | 2R | 2Q | 2N | 2D | 2E | 2s | 2t | 2y | 3P | 3G | 3A | 3C | 3S | 3T | 3V | 3I | 3L | 3M | 3F | 3Y | 3W | 3H | 3K | 3R | 3Q | 3N | 3D | 3E | 3s | 3t | 3y | 4P | 4G | 4A | 4C | 4S | 4T | 4V | 4I | 4L | 4M | 4F | 4Y | 4W | 4H | 4K | 4R | 4Q | 4N | 4D | 4E | 4s | 4t | 4y | 0s | 0t | 0y | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SRC | 0.288615 | 0.937824 | 0.905363 | -1.058492 | -0.441744 | -0.555355 | 0.256155 | 0.045162 | 0.954054 | -0.944880 | -0.328132 | -1.512938 | -1.448017 | -0.798808 | 1.100126 | 0.223695 | 0.158774 | -0.068449 | 1.668183 | 2.463463 | -0.474204 | -0.879959 | -0.490435 | 0.479723 | 1.257423 | 0.593137 | -0.978465 | -0.233169 | -0.670626 | 0.204287 | -0.265573 | 1.435646 | -0.994667 | -0.459998 | -1.415922 | -1.415922 | -0.978465 | 0.350106 | 0.285298 | 0.058468 | 0.042266 | 1.613869 | 2.294357 | 0.058468 | -0.784040 | -0.476201 | 0.251267 | 0.947354 | 1.206363 | -1.302788 | -0.444820 | -0.736205 | 0.299831 | -0.461008 | 0.558840 | -1.140907 | -0.752393 | -1.335164 | -1.416104 | -0.946650 | 0.526464 | 0.008446 | 0.477900 | 0.008446 | 1.821510 | 3.764078 | -0.088682 | -0.849522 | -0.396256 | 0.816792 | 1.431673 | 0.719706 | -1.189660 | -0.574780 | -0.914582 | 0.363722 | -0.315883 | 0.331360 | -1.189660 | -0.623323 | -1.497100 | -1.367652 | -0.833677 | 0.671163 | -0.299702 | 0.201912 | 0.363722 | 2.192183 | 2.483442 | 0.234274 | -0.623323 | -0.380607 | 0.541714 | 0.153368 | 0.849154 | -1.011668 | -0.801315 | -0.801315 | 2.062734 | 1.399311 | 2.192183 | -1.286747 | -0.202615 | -1.416195 | -1.302928 | -0.704228 | -0.315883 | -0.801315 | -0.218796 | -0.315883 | 0.946241 | 1.787656 | -0.445331 | -0.251158 | -0.056985 | -0.847837 | 2.153449 | 0.855596 | -1.107408 | -0.361142 | -1.042515 | 0.709587 | 0.222892 | 0.806926 | -1.091184 | -0.458481 | -1.496764 | -1.366978 | -0.815391 | 0.222892 | -0.361142 | 0.482463 | -0.231356 | 1.715424 | 2.656368 | 0.044437 | -0.636936 | -0.052902 | 0.183643 | 0.868580 | 1.064276 | -1.006844 | -0.354522 | -0.664375 | 0.787040 | 0.004254 | 1.308897 | -0.957920 | -0.550219 | -1.414545 | -1.267772 | -0.908996 | -0.044670 | -0.012054 | 0.199951 | 0.020562 | 1.178433 | 2.287379 | 0.118410 | -0.582835 | -0.256674 | 0.797607 | 0.535536 | 0.781228 | -1.020510 | -0.496368 | -0.823957 | 0.895884 | 0.338983 | 2.468309 | -0.987751 | 0.142430 | -1.151545 | -1.331719 | -0.545506 | 0.126050 | 0.437260 | -0.430850 | -0.332574 | 0.895884 | 1.076058 | -0.348953 | -0.840336 | -0.185159 | 0.623344 | 1.116021 | 0.935373 | -1.133872 | -0.378433 | -0.936801 | 0.656189 | -0.148517 | 1.165289 | -0.838265 | -0.394856 | -1.281675 | -1.265252 | -0.805420 | 1.214557 | 0.935373 | -0.197785 | -0.345588 | 0.968218 | 1.822192 | -0.411278 | -0.903956 | -0.394856 | -0.701944 | -0.712257 | 1.414201 |
| EPHA3 | 0.067908 | 0.886947 | 0.696473 | -1.093984 | -0.427324 | -0.617799 | 0.201240 | -0.236850 | 0.486951 | -0.941604 | -0.293993 | -1.246363 | -1.246363 | -0.636846 | 1.458369 | 0.753615 | 0.410761 | 0.277430 | 1.305990 | 2.086933 | -0.560656 | -0.941604 | -0.389230 | 0.214614 | 1.467628 | 0.746195 | -0.943475 | -0.487833 | -0.715654 | 0.461419 | -0.089147 | 0.898076 | -0.810579 | -0.297983 | -1.399116 | -1.380131 | -0.791594 | 0.803151 | 0.613300 | -0.241028 | -0.203058 | 1.790374 | 1.695448 | -0.127117 | -0.715654 | -0.487833 | 0.384444 | 0.953685 | 1.086508 | -1.190457 | -0.735064 | -0.773013 | 0.441368 | 0.023925 | 1.067534 | -1.114558 | -0.526342 | -1.380204 | -1.342254 | -0.697114 | 0.801888 | 0.213672 | 0.194697 | 0.004950 | 1.219331 | 2.149092 | 0.156748 | -0.848912 | -0.089924 | 0.460343 | 1.162407 | 0.934711 | -1.057634 | -0.564291 | -0.981735 | -0.146848 | 0.004950 | 0.232646 | -1.114558 | -0.810962 | -1.456103 | -1.266355 | -0.886861 | 1.124458 | 0.118798 | 0.365469 | -0.070949 | 1.352154 | 2.566535 | 0.308545 | -0.431468 | 0.156748 | -0.659165 | 0.004950 | 0.365469 | -1.228406 | -0.981735 | -0.829937 | 0.782913 | 0.707014 | 2.187041 | -1.342254 | -0.279671 | -1.456103 | -1.266355 | -0.981735 | -0.184797 | -0.431468 | -0.317620 | 1.048559 | 2.851156 | 2.016269 | -0.260696 | -0.108898 | 0.365469 | -0.999870 | 1.603924 | 1.014744 | -0.961859 | -1.037882 | -1.322969 | 1.375854 | 0.330536 | 0.862698 | -0.809812 | -0.638760 | -1.437003 | -1.189928 | -0.695777 | -0.277650 | -0.790806 | 0.577611 | -0.448702 | 1.908017 | 3.580527 | -0.144609 | -0.828818 | 0.330536 | -0.098097 | 0.341678 | 1.010901 | -1.035010 | -0.901165 | -1.035010 | 0.666729 | -0.327545 | 0.743212 | -0.977648 | -0.346666 | -1.417423 | -1.168855 | -0.805562 | 0.188713 | -0.327545 | -0.155459 | 0.073989 | 2.750882 | 2.980330 | 0.112230 | -0.537873 | 0.265195 | 0.524962 | 0.428830 | 0.794130 | -0.840106 | -0.840106 | -0.897785 | 1.255561 | 0.544188 | 3.178192 | -0.840106 | -0.109506 | -1.378443 | -1.359216 | -0.705522 | -0.205638 | 0.294246 | -0.282543 | -0.551711 | 1.005619 | 0.794130 | -0.301769 | -0.494032 | -0.013375 | 0.335763 | 0.817219 | 0.952026 | -0.973796 | -0.222726 | -0.742698 | 0.643895 | -0.184209 | 0.701669 | -0.819731 | -0.261242 | -1.301186 | -1.166379 | -0.761956 | 0.701669 | 0.374279 | -0.164951 | 0.104664 | 1.163867 | 1.876421 | -0.319017 | -0.588632 | -0.164951 | -0.683583 | -0.730373 | 1.413956 |
| FES | 0.326894 | 0.640167 | 1.204058 | -1.030623 | -0.341422 | -0.717350 | 0.326894 | -0.049034 | 0.828130 | -1.114162 | -0.383192 | -1.448320 | -1.364781 | -0.821774 | 1.579985 | 0.013621 | 0.264239 | 0.076275 | 1.642640 | 2.310956 | -0.466731 | -0.926198 | -0.550271 | 0.678069 | 1.136762 | 0.490421 | -0.864810 | -0.552064 | -0.531214 | 0.594670 | -0.239318 | 1.220161 | -0.906509 | -0.176769 | -1.427752 | -1.386052 | -0.948208 | 0.657219 | 0.261075 | -0.218469 | 0.010878 | 1.741404 | 1.762253 | -0.051671 | -0.739711 | -0.510365 | 0.176670 | 0.926839 | 1.551979 | -1.156963 | -0.677688 | -0.990259 | 0.343374 | -0.344280 | 0.989353 | -1.115287 | -0.761040 | -1.490371 | -1.490371 | -0.844392 | 0.864325 | 0.239184 | 0.489240 | -0.052548 | 1.677007 | 2.552204 | -0.094224 | -0.781878 | -0.010872 | 0.572592 | 1.218571 | 0.760134 | -1.115287 | -0.802716 | -1.094449 | 0.385050 | -0.219252 | 0.489240 | -1.136125 | -0.906907 | -1.532047 | -1.240315 | -0.948583 | 1.322761 | -0.302604 | 0.385050 | 0.155832 | 1.739521 | 2.677232 | 0.260022 | -0.531822 | -0.135900 | 0.051642 | 0.155832 | 0.906001 | -1.115287 | -0.969421 | -1.094449 | 1.260247 | 0.968515 | 2.177119 | -1.281991 | 0.009966 | -1.552885 | -1.302829 | -0.698526 | 0.093318 | -0.469308 | -0.031710 | 0.197508 | 1.656169 | 1.572817 | -0.406794 | -0.156738 | 0.030804 | -0.570568 | 1.728059 | 1.289230 | -1.030294 | -0.758638 | -1.155673 | 0.850401 | 0.139916 | 0.578745 | -1.134777 | -0.633258 | -1.531813 | -1.427329 | -0.758638 | -0.027256 | -0.779534 | 0.578745 | -0.215326 | 2.187784 | 3.190822 | 0.202606 | -0.654155 | -0.069050 | 0.374255 | 0.688411 | 0.876905 | -1.049918 | -0.966143 | -1.028975 | 0.876905 | 0.164818 | 1.337667 | -0.966143 | -0.149338 | -1.573511 | -1.091806 | -0.840481 | 0.269537 | -0.400663 | -0.275000 | 0.122931 | 2.007866 | 2.154472 | -0.086507 | -0.337831 | -0.107450 | 0.107815 | 0.696230 | 0.801304 | -1.005970 | -0.795822 | -1.090029 | 0.759274 | 0.465067 | 2.167266 | -0.816836 | -0.228422 | -1.510325 | -1.279162 | -0.816836 | 0.191874 | 0.170860 | -0.018274 | -0.396540 | 1.620881 | 1.536822 | -0.207407 | -0.459585 | 0.107815 | 0.257037 | 1.077542 | 1.308967 | -1.047357 | -0.479314 | -0.836971 | 1.014427 | -0.311005 | 1.266890 | -1.026318 | -0.332044 | -1.341897 | -1.236704 | -0.836971 | 1.035465 | 0.488462 | -0.058542 | -0.163735 | 1.014427 | 1.498315 | -0.226851 | -0.668662 | -0.395160 | -0.693206 | -0.720917 | 1.414123 |
| NTRK3 | 0.246599 | 0.825353 | 0.917953 | -1.211859 | -0.517355 | -0.563656 | 0.223449 | -0.054352 | 1.126304 | -1.165559 | -0.494205 | -1.535961 | -1.535961 | -0.957208 | 1.728208 | 0.570701 | 0.038248 | 0.246599 | 1.589307 | 2.191211 | -0.517355 | -0.702556 | -0.447905 | 0.611505 | 1.327439 | 1.050303 | -0.912740 | -0.866550 | -0.843456 | 0.519127 | -0.081333 | 1.581479 | -0.889645 | -0.196806 | -1.536294 | -1.443916 | -0.935834 | 0.565316 | 0.542222 | -0.150617 | -0.081333 | 1.281249 | 1.535290 | -0.081333 | -0.751077 | -0.242996 | 0.310085 | 1.071751 | 1.833417 | -1.236327 | -0.890115 | -1.005519 | 0.563974 | -0.174611 | 1.094832 | -1.213246 | -0.728550 | -1.559458 | -1.420973 | -0.705469 | 1.071751 | 0.310085 | 0.033116 | 0.263924 | 1.094832 | 1.833417 | 0.194681 | -0.497742 | -0.243853 | 0.308897 | 1.254642 | 1.162374 | -1.005920 | -1.075121 | -1.236590 | 0.124361 | 0.101294 | 0.839437 | -1.075121 | -0.567648 | -1.582594 | -1.328858 | -1.052054 | 1.139307 | -0.175510 | 0.101294 | 0.170495 | 1.900517 | 2.384923 | 0.147428 | -0.383112 | -0.152443 | -0.106309 | 0.908638 | 1.323843 | -1.052054 | -1.190456 | -1.236590 | 0.493432 | 0.124361 | 1.831316 | -1.490326 | -0.290844 | -1.651795 | -1.328858 | -0.798317 | 0.078227 | -0.360045 | -0.014041 | 0.908638 | 1.831316 | 1.393044 | 0.078227 | -0.198576 | 0.747169 | -0.797266 | 1.696953 | 1.073398 | -0.912740 | -1.236064 | -1.282254 | 1.881710 | 0.611505 | 1.581479 | -1.051307 | -0.081333 | -1.674862 | -1.490105 | -0.704888 | 0.218897 | -0.704888 | 0.057234 | -0.312279 | 1.004114 | 1.789331 | 0.126518 | -0.266090 | 0.472938 | 0.158406 | 0.947407 | 1.689996 | -0.909067 | -1.117920 | -1.117920 | 0.970613 | 0.088788 | 1.202672 | -1.001890 | -0.352125 | -1.628450 | -1.233950 | -1.071508 | 0.552906 | -0.143271 | -0.027242 | 0.042376 | 1.272290 | 1.922056 | 0.251229 | -0.398536 | -0.096859 | 0.396704 | 1.094985 | 1.327746 | -0.813649 | -0.860201 | -1.139513 | 1.164813 | 0.326876 | 2.538099 | -0.976581 | -0.441233 | -1.605034 | -1.418826 | -0.836925 | 0.303600 | 0.210496 | -0.278300 | -0.301576 | 1.118261 | 1.025157 | -0.045540 | -0.511061 | -0.278300 | 0.097329 | 1.216607 | 1.146652 | -1.045268 | -0.532265 | -1.138541 | 0.890151 | -0.112536 | 1.263243 | -0.695494 | -0.555584 | -1.558271 | -1.278451 | -0.882040 | 1.169970 | 0.237238 | -0.182491 | -0.019263 | 1.100015 | 1.636336 | -0.089218 | -0.578902 | -0.089218 | -0.648459 | -0.764176 | 1.412635 |
| ALK | -0.000966 | 0.532096 | 1.154002 | -1.222566 | -0.378551 | -0.600660 | 0.132300 | -0.200864 | 0.776416 | -1.067090 | -0.689504 | -1.378042 | -1.244777 | -0.689504 | 1.487166 | 0.665362 | 0.154511 | 0.265565 | 1.909173 | 2.442235 | -0.489606 | -0.889402 | -0.667293 | 0.169237 | 1.363510 | 0.899070 | -0.870223 | -0.450016 | -0.936572 | 0.301934 | -0.317319 | 1.518323 | -0.781759 | -0.427900 | -1.445244 | -1.401011 | -0.980804 | 0.832722 | 0.943303 | -0.206738 | -0.206738 | 1.341394 | 2.093344 | -0.074041 | -0.848107 | -0.516364 | 0.146070 | 0.764946 | 1.428027 | -1.135887 | -1.025373 | -0.936962 | 0.433405 | -0.318087 | 1.273308 | -1.157989 | -0.760141 | -1.467427 | -1.379016 | -0.738038 | 1.140692 | 0.344994 | 0.278686 | -0.052854 | 1.317513 | 2.908908 | 0.013454 | -0.804346 | -0.273881 | 0.299645 | 1.183215 | 0.763520 | -1.047799 | -0.893174 | -0.981531 | 0.078753 | -0.142140 | 0.454270 | -1.069888 | -0.848995 | -1.533762 | -1.312870 | -0.981531 | 1.337840 | -0.097961 | 0.388002 | 0.167110 | 2.110964 | 2.508570 | 0.189199 | -0.628103 | 0.056664 | 0.189199 | 0.608895 | 0.918144 | -1.224513 | -1.047799 | -1.246602 | 1.315751 | 0.896055 | 2.177232 | -1.379137 | -0.628103 | -1.555851 | -1.334959 | -1.025709 | -0.009604 | -0.407210 | -0.385121 | 0.233378 | 1.845893 | 1.912161 | -0.186318 | -0.274675 | 0.608895 | -0.870654 | 1.538540 | 1.229102 | -0.826449 | -1.069579 | -1.202195 | 1.405924 | 0.477611 | 1.162794 | -0.936962 | -0.384395 | -1.533735 | -1.312708 | -0.782243 | 0.322892 | -0.428600 | 0.300789 | -0.472806 | 1.052281 | 2.599470 | 0.168173 | -0.649627 | 0.212378 | 0.369469 | 0.657155 | 1.365304 | -0.869792 | -1.068959 | -1.179607 | 1.188266 | 0.192432 | 1.321044 | -0.847662 | -0.205902 | -1.467292 | -1.268125 | -0.936181 | 0.767803 | 0.280950 | -0.050994 | -0.006735 | 0.789932 | 1.520211 | -0.028865 | -0.515717 | -0.006735 | 0.171369 | 0.304228 | 0.525659 | -0.692214 | -0.825073 | -1.046505 | 1.832106 | 0.813520 | 2.673546 | -0.913646 | -0.227208 | -1.400795 | -1.201507 | -0.780787 | 0.259941 | 0.990666 | -0.426496 | -0.426496 | 0.459230 | 0.636375 | -0.249351 | -0.404353 | -0.072206 | 0.238907 | 0.615570 | 1.235957 | -0.979710 | -0.603047 | -0.979710 | 0.704197 | 0.194593 | 1.324584 | -0.891084 | -0.204227 | -1.312061 | -1.179120 | -0.846770 | 1.501837 | 0.571257 | -0.204227 | -0.115600 | 0.947920 | 1.058704 | -0.292853 | -0.514420 | -0.270697 | -0.688690 | -0.725365 | 1.414055 |
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| VRK2 | 0.913815 | 0.836508 | 0.449975 | 0.527282 | -0.158815 | -0.158815 | -0.158815 | -0.767604 | -0.777268 | -0.661308 | -0.158815 | 0.643242 | 0.382332 | 0.933142 | -0.129825 | 0.285698 | -0.458378 | -0.545348 | -0.187805 | -0.796594 | 0.053779 | 0.053779 | -0.120161 | 1.238276 | 1.354168 | 0.658818 | 0.687791 | -0.239341 | -0.239341 | -0.036531 | -0.722223 | -0.722223 | -0.239341 | -0.258657 | 0.320801 | 0.581557 | 0.204910 | -0.326260 | 0.233883 | -0.654619 | -0.490440 | -0.896060 | -0.490440 | -0.017216 | -0.017216 | 0.069703 | 1.617455 | 1.392879 | 0.416463 | 0.133302 | -0.061981 | -0.061981 | -0.315849 | -0.374434 | -0.335378 | -0.061981 | -0.120566 | 0.416463 | 0.367642 | 0.738680 | -0.638067 | 0.367642 | -0.647831 | -0.032689 | -1.028633 | -0.930992 | -0.393963 | -0.393963 | -0.052217 | 0.658854 | 3.601795 | 0.199955 | 0.170027 | -0.009542 | -0.009542 | -0.548250 | -0.857508 | 0.209931 | 1.087825 | 0.050314 | -0.209064 | -0.039471 | 0.409453 | -0.308824 | 0.499237 | -0.009542 | -0.029494 | -0.787676 | -0.977221 | -1.047054 | -1.047054 | -1.007149 | 0.689069 | -0.112765 | -0.201857 | -0.201857 | 0.223808 | 0.223808 | 1.391911 | 0.293102 | 0.986044 | 0.223808 | -0.686917 | 0.283203 | -0.597824 | 2.421426 | 0.372295 | 0.500985 | -0.370143 | -0.132563 | -1.102683 | -1.795625 | -0.865102 | -0.865102 | -0.677018 | 1.216846 | 0.411378 | -0.261544 | -0.740747 | -0.006649 | -0.006649 | 3.470116 | 1.675657 | -0.924271 | 0.340008 | -0.404285 | -0.006649 | 0.574511 | -0.648984 | -0.006649 | 3.694424 | 1.104692 | -1.148578 | -2.229333 | -1.739934 | -1.811305 | -1.811305 | -0.740747 | -1.547487 | 0.847371 | -0.244845 | 0.216091 | 0.105867 | 0.105867 | 0.616904 | 2.210136 | 2.160034 | 1.809323 | 1.568835 | 1.198083 | 1.969648 | 0.105867 | -0.254865 | -0.765902 | -0.545454 | -1.417223 | -2.028463 | -2.309032 | -1.657711 | -1.657711 | -0.485332 | -1.216215 | 1.073850 | 0.200009 | -0.231889 | -0.171624 | -0.171624 | -0.171624 | -0.342374 | -0.402639 | -0.543257 | 0.501334 | 0.742393 | 3.755636 | 1.857293 | -0.523169 | 2.389633 | -0.523169 | 0.491290 | -1.708378 | -1.979570 | -1.366877 | -1.366877 | -0.292154 | 0.050297 | 0.827835 | 0.296833 | -0.243651 | -0.243651 | -0.243651 | -0.613456 | -0.784135 | -0.471223 | -0.376401 | 0.097708 | 0.249422 | 1.671749 | 0.666638 | -0.746206 | -0.471223 | -0.651384 | -0.234169 | -0.243651 | -1.286690 | 0.306316 | 0.306316 | 2.136376 | -0.134920 | 1.286619 | -1.151698 |
| WNK4 | -0.787779 | -0.171271 | -0.107219 | -0.087202 | 0.056916 | 0.056916 | -0.167268 | 0.261085 | 0.409207 | 0.056916 | 0.589355 | 0.869586 | 0.689437 | 0.593358 | 0.713457 | 1.746308 | -0.759756 | -0.363430 | -1.112046 | -0.935901 | -0.543578 | -0.543578 | -0.463512 | -0.640355 | 0.075796 | -0.112449 | -0.186110 | -0.112449 | -0.112449 | -0.153372 | -0.096080 | -0.362079 | -0.042880 | -0.186110 | 0.464564 | 0.231304 | 0.640533 | 1.573576 | 3.001786 | -0.149280 | -0.177926 | -0.873616 | -0.783585 | -0.501217 | -0.501217 | -0.996385 | -0.076874 | 0.231143 | -0.080874 | -0.020871 | -0.076874 | -0.076874 | -0.008870 | -0.036872 | -0.192880 | 0.127138 | -0.504898 | 0.003131 | -0.596903 | 0.459156 | 1.595219 | 3.991352 | -0.520899 | -0.508898 | -1.348945 | -1.032927 | -0.360890 | -0.360890 | -0.600903 | 0.917850 | 4.265395 | 1.354307 | 0.234341 | -0.276232 | -0.276232 | 0.090227 | -0.440933 | -0.720925 | -0.552106 | -0.276232 | -0.259762 | -0.663279 | 1.465480 | 0.234341 | 1.959583 | -0.877390 | -0.778570 | -1.527959 | -1.527959 | -0.609751 | -0.609751 | -1.124442 | -1.161009 | 0.607030 | 0.511573 | 0.316508 | -0.231336 | -0.231336 | -0.281140 | -0.318492 | -0.231336 | 1.590658 | -0.343394 | 0.308207 | -0.708623 | 0.299906 | 1.794024 | 4.271769 | 0.059187 | -0.712773 | -1.563590 | -1.123656 | -1.181760 | -1.181760 | -0.488656 | -1.683890 | -0.145187 | -0.681278 | 1.008839 | 0.075796 | 0.075796 | 0.075796 | 0.628256 | 1.160254 | 2.449327 | 0.464564 | 0.988378 | 0.083981 | -0.308879 | -0.055157 | 2.228343 | 0.542318 | 0.010320 | -1.667521 | -1.671613 | -1.336045 | -1.336045 | -0.906354 | -1.487522 | 0.483187 | 0.129790 | 0.179681 | 0.125632 | 0.125632 | 0.558024 | 2.121287 | 0.765905 | 0.948840 | 0.125632 | 0.262833 | -0.186189 | 0.113159 | -0.132140 | 3.023489 | -0.988608 | -0.643526 | -0.872195 | -1.159070 | -1.271326 | -1.271326 | -0.951190 | -0.995206 | -0.404314 | -0.559371 | -0.035530 | 0.002186 | 0.002186 | -0.173824 | 0.002186 | 0.245248 | 0.291346 | 2.923121 | 1.334837 | 1.749719 | 1.058249 | 0.345826 | 0.743945 | -0.869484 | -0.563561 | -0.735381 | -0.986825 | -1.309510 | -1.309510 | -0.756335 | -0.567130 | -0.202433 | -0.153807 | 0.137950 | 0.044750 | 0.044750 | 0.044750 | 0.693100 | -0.072763 | 0.364873 | 0.826822 | 0.583691 | 0.891657 | 0.413499 | 0.802509 | 1.110475 | -0.660330 | -0.332103 | -0.976401 | -0.745426 | -0.794052 | -0.794052 | -0.660330 | 0.514442 | 0.883617 | -1.398059 |
| YANK2 | -0.069665 | 0.063579 | -0.005842 | -0.045031 | -0.069665 | -0.069665 | -0.234261 | -0.192832 | -0.205148 | -0.193951 | -0.101016 | 0.009834 | -0.162600 | 0.031108 | 0.167712 | 0.195704 | -0.139086 | -0.039433 | -0.010321 | -0.140206 | 0.381574 | 0.381574 | 0.447636 | -0.046635 | 0.037552 | -0.047674 | -0.123546 | -0.123546 | -0.123546 | -0.252425 | -0.315825 | -0.263858 | -0.165120 | -0.227481 | -0.167199 | -0.239953 | -0.123546 | -0.045596 | 0.085362 | -0.180710 | -0.118350 | -0.014415 | 0.254775 | 1.038440 | 1.038440 | 0.124857 | -0.313425 | -0.360362 | -0.326835 | -0.324824 | -0.360362 | -0.360362 | -0.395229 | -0.442165 | -0.415344 | -0.412662 | -0.421379 | -0.358350 | -0.462951 | -0.375113 | -0.303367 | 0.137165 | -0.422049 | -0.347622 | -0.112939 | -0.185355 | 3.159876 | 3.159876 | 0.243778 | -0.063168 | -0.323353 | -0.219643 | -0.047702 | -0.219643 | -0.219643 | -0.292422 | -0.306978 | 0.188830 | -0.074994 | 0.002334 | -0.047702 | -0.315166 | -0.066807 | -0.367931 | -0.172336 | -0.247845 | -0.172336 | -0.419786 | -0.226011 | 0.209755 | 0.209755 | 3.192793 | 0.301826 | 0.160395 | -0.064230 | -0.010748 | -0.064230 | -0.064230 | -0.304306 | -0.329264 | -0.101074 | 0.084331 | -0.137917 | 0.095028 | -0.275782 | -0.026199 | 0.204369 | 0.696406 | 0.003514 | -0.105828 | -0.330453 | -0.211604 | -0.002429 | -0.002429 | 0.484854 | -0.544935 | -0.456711 | -0.330677 | -0.021321 | -0.091213 | -0.091213 | 0.132211 | 0.566455 | 0.024509 | 0.729153 | 0.840292 | -0.043091 | -0.237870 | -0.190894 | -0.213809 | -0.086630 | -0.039653 | -0.351301 | -0.475043 | -0.091213 | 0.037113 | 0.037113 | 0.898726 | -0.678916 | -0.668713 | -0.626626 | -0.534799 | -0.553610 | -0.553610 | -0.575611 | -0.550741 | -0.575292 | -0.544045 | -0.532567 | -0.229665 | -0.458595 | -0.418102 | -0.569871 | -0.530335 | -0.557755 | -0.587089 | -0.553610 | -0.378884 | -0.293752 | -0.293752 | 11.265940 | -0.543125 | -0.506080 | -0.350320 | -0.270336 | -0.173513 | -0.173513 | -0.023648 | 0.010872 | -0.079216 | -0.137310 | -0.042170 | -0.103632 | -0.019438 | -0.168461 | -0.173513 | -0.197929 | -0.309907 | -0.392418 | -0.417676 | -0.351162 | 0.975736 | 0.975736 | 2.471022 | -0.168368 | -0.304390 | -0.333419 | -0.362448 | -0.297755 | -0.297755 | -0.356642 | -0.213156 | -0.322637 | -0.281167 | -0.355813 | -0.236379 | -0.165051 | -0.152610 | 0.179980 | 0.192421 | -0.297755 | -0.315172 | -0.456170 | -0.344201 | 0.189103 | 0.189103 | 4.510281 | 0.213252 | 1.104115 | -1.317366 |
| YANK3 | 0.036918 | 0.227998 | 0.064757 | 0.002751 | -0.064317 | -0.064317 | -0.118731 | -0.074440 | -0.044070 | -0.066848 | -0.065582 | -0.064317 | -0.044070 | -0.112403 | 0.026794 | 0.307720 | -0.174410 | -0.097218 | 0.128029 | -0.093422 | 0.122967 | 0.122967 | 0.043245 | 0.055050 | 0.259423 | 0.032073 | -0.042904 | -0.092486 | -0.092486 | -0.126346 | -0.177137 | -0.217045 | -0.085230 | -0.213417 | -0.165044 | -0.142067 | -0.210998 | -0.069509 | 0.225562 | -0.157788 | -0.092486 | 0.229190 | 0.130027 | 0.472261 | 0.472261 | 0.009096 | -0.236397 | -0.265901 | -0.285289 | -0.311421 | -0.355255 | -0.355255 | -0.350197 | -0.378015 | -0.371271 | -0.384759 | -0.450510 | -0.355255 | -0.407519 | -0.434494 | -0.282760 | 1.072728 | -0.359470 | -0.377172 | -0.279388 | -0.242298 | 2.736742 | 2.736742 | -0.063589 | 0.000460 | -0.119404 | -0.157008 | 0.082719 | -0.140556 | -0.140556 | -0.239268 | -0.219291 | 0.164979 | 0.021612 | -0.034794 | -0.124105 | -0.140556 | -0.135856 | -0.182861 | 0.967597 | -0.184037 | -0.172285 | -0.310951 | -0.200488 | 0.129725 | 0.129725 | 1.005201 | 0.546474 | 0.190063 | -0.171457 | -0.142075 | -0.116526 | -0.116526 | -0.167625 | -0.309422 | -0.145908 | 0.064873 | -0.199561 | -0.070538 | -0.249382 | -0.116526 | 0.100641 | 0.727873 | 0.055930 | 0.027826 | -0.148463 | -0.177844 | 0.054653 | 0.054653 | 0.308867 | -0.465117 | -0.361424 | -0.328094 | -0.112066 | -0.086143 | -0.086143 | 0.073101 | 0.637242 | -0.052813 | 0.532314 | 0.758217 | -0.086143 | -0.126879 | -0.326860 | -0.266372 | 0.017551 | 0.102727 | -0.281185 | -0.354017 | 0.055818 | -0.009607 | -0.009607 | 0.775500 | -0.689165 | -0.652955 | -0.644131 | -0.490467 | -0.609138 | -0.609138 | -0.609138 | -0.570190 | -0.540978 | -0.558322 | -0.536718 | -0.387315 | -0.317938 | -0.567451 | -0.651738 | -0.621005 | -0.626178 | -0.618875 | -0.630438 | -0.552237 | -0.278076 | -0.278076 | 12.039666 | -0.463843 | -0.388116 | -0.340672 | -0.189218 | -0.233925 | -0.233925 | -0.038677 | 0.055298 | -0.233925 | -0.247610 | -0.174620 | -0.121703 | -0.103455 | -0.165497 | -0.188306 | -0.091594 | -0.261296 | -0.305090 | -0.383554 | -0.240311 | 1.003254 | 1.003254 | 2.343530 | -0.131072 | -0.287017 | -0.247593 | -0.356229 | -0.247593 | -0.247593 | -0.343088 | -0.322937 | -0.325566 | -0.294902 | -0.371999 | -0.290522 | -0.211673 | -0.227443 | -0.141585 | -0.111798 | -0.200284 | -0.242336 | -0.308044 | 0.001219 | 0.300844 | 0.300844 | 4.306364 | 0.817024 | 0.591165 | -1.408189 |
| YSK4 | -0.032950 | 0.568875 | 0.640203 | 0.595623 | -0.015118 | -0.015118 | -0.371756 | -0.893337 | -0.746225 | -0.394045 | 0.158742 | -0.001744 | 0.689240 | 0.283565 | -0.336092 | -0.015118 | -0.532242 | 0.069583 | 0.408388 | -0.411877 | 0.457426 | 0.457426 | -0.563448 | 0.108431 | 0.381554 | 0.090522 | 0.242754 | 0.090522 | 0.090522 | -0.540794 | -0.831827 | -0.352743 | -0.124394 | 0.054702 | 0.099477 | 0.520354 | 0.126341 | -0.478111 | -0.334833 | -0.209465 | 0.229322 | 0.327825 | 0.211412 | 0.292006 | 0.292006 | -0.285581 | -0.156075 | 0.392044 | -0.111147 | 0.180883 | -0.111147 | -0.111147 | -1.077095 | -0.960282 | -0.758107 | -0.165061 | -0.241438 | 0.091028 | 0.531320 | 0.171898 | -0.358250 | -0.236945 | 0.082042 | 0.989583 | 1.187265 | 0.046100 | 0.203347 | 0.203347 | 0.207840 | -0.756930 | 0.055572 | 0.179110 | 0.117341 | -0.286534 | -0.286534 | -1.004006 | -1.118041 | -1.260585 | -0.381564 | 1.975165 | 3.410109 | 2.341028 | 1.077137 | -1.659709 | -1.322355 | -0.286534 | 0.340660 | 0.725529 | -0.300789 | -0.604883 | -0.604883 | -0.348303 | 0.278396 | -0.303281 | -0.345162 | -0.629020 | -0.098531 | -0.098531 | -0.991987 | -1.071095 | 0.422652 | 0.152753 | -0.396350 | 1.116011 | -0.373083 | 0.753044 | 0.064339 | -0.172986 | -0.098531 | 0.743737 | 1.441750 | -0.177639 | -0.610407 | -0.610407 | 1.004329 | -2.088449 | -1.134681 | -1.347178 | 0.244082 | -1.134681 | -1.134681 | 0.713553 | 2.270221 | 3.723111 | 1.869935 | 1.192908 | 1.894644 | 5.171060 | 0.229257 | -1.525083 | -1.416364 | -1.268110 | -1.164332 | -1.648628 | -1.554734 | -0.393410 | -0.393410 | -1.105030 | -0.860170 | -0.401302 | -0.802812 | -0.468220 | -0.774132 | -0.774132 | -0.195767 | -0.774132 | -1.132623 | -0.917529 | -0.974887 | -0.554258 | -0.783692 | 1.113919 | 3.594675 | 5.755180 | -0.057151 | 1.348133 | -0.812371 | -1.247340 | 0.535554 | 0.535554 | -1.352497 | 0.768778 | 0.442187 | -0.233993 | -0.169595 | -0.017799 | -0.017799 | -0.192594 | -0.670981 | -0.463987 | -0.500786 | -0.040799 | -0.017799 | 0.198394 | 0.290392 | 0.883775 | 0.529585 | -0.008600 | 0.635382 | -0.509985 | -0.606583 | 0.276592 | 0.276592 | -0.850376 | 0.963629 | 0.645691 | -0.036261 | -0.109986 | -0.036261 | -0.036261 | -0.626058 | -0.506256 | -0.460178 | -0.340375 | -0.552333 | -0.404884 | -0.192926 | 0.350793 | 1.074215 | 0.171089 | 0.737847 | 0.180305 | 0.019032 | -0.446354 | 0.244814 | 0.244814 | -0.884094 | 0.450034 | 0.936061 | -1.386095 |
390 rows × 210 columns
# get the index column out and rename it with 'kinase'
target = v.reset_index().rename(columns={'index':'kinase'})target| kinase | -5P | -5G | -5A | -5C | -5S | -5T | -5V | -5I | -5L | -5M | -5F | -5Y | -5W | -5H | -5K | -5R | -5Q | -5N | -5D | -5E | -5s | -5t | -5y | -4P | -4G | -4A | -4C | -4S | -4T | -4V | -4I | -4L | -4M | -4F | -4Y | -4W | -4H | -4K | -4R | -4Q | -4N | -4D | -4E | -4s | -4t | -4y | -3P | -3G | -3A | -3C | -3S | -3T | -3V | -3I | -3L | -3M | -3F | -3Y | -3W | -3H | -3K | -3R | -3Q | -3N | -3D | -3E | -3s | -3t | -3y | -2P | -2G | -2A | -2C | -2S | -2T | -2V | -2I | -2L | -2M | -2F | -2Y | -2W | -2H | -2K | -2R | -2Q | -2N | -2D | -2E | -2s | -2t | -2y | -1P | -1G | -1A | -1C | -1S | -1T | -1V | -1I | -1L | -1M | -1F | -1Y | -1W | -1H | -1K | -1R | -1Q | -1N | -1D | -1E | -1s | -1t | -1y | 1P | 1G | 1A | 1C | 1S | 1T | 1V | 1I | 1L | 1M | 1F | 1Y | 1W | 1H | 1K | 1R | 1Q | 1N | 1D | 1E | 1s | 1t | 1y | 2P | 2G | 2A | 2C | 2S | 2T | 2V | 2I | 2L | 2M | 2F | 2Y | 2W | 2H | 2K | 2R | 2Q | 2N | 2D | 2E | 2s | 2t | 2y | 3P | 3G | 3A | 3C | 3S | 3T | 3V | 3I | 3L | 3M | 3F | 3Y | 3W | 3H | 3K | 3R | 3Q | 3N | 3D | 3E | 3s | 3t | 3y | 4P | 4G | 4A | 4C | 4S | 4T | 4V | 4I | 4L | 4M | 4F | 4Y | 4W | 4H | 4K | 4R | 4Q | 4N | 4D | 4E | 4s | 4t | 4y | 0s | 0t | 0y | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | SRC | 0.288615 | 0.937824 | 0.905363 | -1.058492 | -0.441744 | -0.555355 | 0.256155 | 0.045162 | 0.954054 | -0.944880 | -0.328132 | -1.512938 | -1.448017 | -0.798808 | 1.100126 | 0.223695 | 0.158774 | -0.068449 | 1.668183 | 2.463463 | -0.474204 | -0.879959 | -0.490435 | 0.479723 | 1.257423 | 0.593137 | -0.978465 | -0.233169 | -0.670626 | 0.204287 | -0.265573 | 1.435646 | -0.994667 | -0.459998 | -1.415922 | -1.415922 | -0.978465 | 0.350106 | 0.285298 | 0.058468 | 0.042266 | 1.613869 | 2.294357 | 0.058468 | -0.784040 | -0.476201 | 0.251267 | 0.947354 | 1.206363 | -1.302788 | -0.444820 | -0.736205 | 0.299831 | -0.461008 | 0.558840 | -1.140907 | -0.752393 | -1.335164 | -1.416104 | -0.946650 | 0.526464 | 0.008446 | 0.477900 | 0.008446 | 1.821510 | 3.764078 | -0.088682 | -0.849522 | -0.396256 | 0.816792 | 1.431673 | 0.719706 | -1.189660 | -0.574780 | -0.914582 | 0.363722 | -0.315883 | 0.331360 | -1.189660 | -0.623323 | -1.497100 | -1.367652 | -0.833677 | 0.671163 | -0.299702 | 0.201912 | 0.363722 | 2.192183 | 2.483442 | 0.234274 | -0.623323 | -0.380607 | 0.541714 | 0.153368 | 0.849154 | -1.011668 | -0.801315 | -0.801315 | 2.062734 | 1.399311 | 2.192183 | -1.286747 | -0.202615 | -1.416195 | -1.302928 | -0.704228 | -0.315883 | -0.801315 | -0.218796 | -0.315883 | 0.946241 | 1.787656 | -0.445331 | -0.251158 | -0.056985 | -0.847837 | 2.153449 | 0.855596 | -1.107408 | -0.361142 | -1.042515 | 0.709587 | 0.222892 | 0.806926 | -1.091184 | -0.458481 | -1.496764 | -1.366978 | -0.815391 | 0.222892 | -0.361142 | 0.482463 | -0.231356 | 1.715424 | 2.656368 | 0.044437 | -0.636936 | -0.052902 | 0.183643 | 0.868580 | 1.064276 | -1.006844 | -0.354522 | -0.664375 | 0.787040 | 0.004254 | 1.308897 | -0.957920 | -0.550219 | -1.414545 | -1.267772 | -0.908996 | -0.044670 | -0.012054 | 0.199951 | 0.020562 | 1.178433 | 2.287379 | 0.118410 | -0.582835 | -0.256674 | 0.797607 | 0.535536 | 0.781228 | -1.020510 | -0.496368 | -0.823957 | 0.895884 | 0.338983 | 2.468309 | -0.987751 | 0.142430 | -1.151545 | -1.331719 | -0.545506 | 0.126050 | 0.437260 | -0.430850 | -0.332574 | 0.895884 | 1.076058 | -0.348953 | -0.840336 | -0.185159 | 0.623344 | 1.116021 | 0.935373 | -1.133872 | -0.378433 | -0.936801 | 0.656189 | -0.148517 | 1.165289 | -0.838265 | -0.394856 | -1.281675 | -1.265252 | -0.805420 | 1.214557 | 0.935373 | -0.197785 | -0.345588 | 0.968218 | 1.822192 | -0.411278 | -0.903956 | -0.394856 | -0.701944 | -0.712257 | 1.414201 |
| 1 | EPHA3 | 0.067908 | 0.886947 | 0.696473 | -1.093984 | -0.427324 | -0.617799 | 0.201240 | -0.236850 | 0.486951 | -0.941604 | -0.293993 | -1.246363 | -1.246363 | -0.636846 | 1.458369 | 0.753615 | 0.410761 | 0.277430 | 1.305990 | 2.086933 | -0.560656 | -0.941604 | -0.389230 | 0.214614 | 1.467628 | 0.746195 | -0.943475 | -0.487833 | -0.715654 | 0.461419 | -0.089147 | 0.898076 | -0.810579 | -0.297983 | -1.399116 | -1.380131 | -0.791594 | 0.803151 | 0.613300 | -0.241028 | -0.203058 | 1.790374 | 1.695448 | -0.127117 | -0.715654 | -0.487833 | 0.384444 | 0.953685 | 1.086508 | -1.190457 | -0.735064 | -0.773013 | 0.441368 | 0.023925 | 1.067534 | -1.114558 | -0.526342 | -1.380204 | -1.342254 | -0.697114 | 0.801888 | 0.213672 | 0.194697 | 0.004950 | 1.219331 | 2.149092 | 0.156748 | -0.848912 | -0.089924 | 0.460343 | 1.162407 | 0.934711 | -1.057634 | -0.564291 | -0.981735 | -0.146848 | 0.004950 | 0.232646 | -1.114558 | -0.810962 | -1.456103 | -1.266355 | -0.886861 | 1.124458 | 0.118798 | 0.365469 | -0.070949 | 1.352154 | 2.566535 | 0.308545 | -0.431468 | 0.156748 | -0.659165 | 0.004950 | 0.365469 | -1.228406 | -0.981735 | -0.829937 | 0.782913 | 0.707014 | 2.187041 | -1.342254 | -0.279671 | -1.456103 | -1.266355 | -0.981735 | -0.184797 | -0.431468 | -0.317620 | 1.048559 | 2.851156 | 2.016269 | -0.260696 | -0.108898 | 0.365469 | -0.999870 | 1.603924 | 1.014744 | -0.961859 | -1.037882 | -1.322969 | 1.375854 | 0.330536 | 0.862698 | -0.809812 | -0.638760 | -1.437003 | -1.189928 | -0.695777 | -0.277650 | -0.790806 | 0.577611 | -0.448702 | 1.908017 | 3.580527 | -0.144609 | -0.828818 | 0.330536 | -0.098097 | 0.341678 | 1.010901 | -1.035010 | -0.901165 | -1.035010 | 0.666729 | -0.327545 | 0.743212 | -0.977648 | -0.346666 | -1.417423 | -1.168855 | -0.805562 | 0.188713 | -0.327545 | -0.155459 | 0.073989 | 2.750882 | 2.980330 | 0.112230 | -0.537873 | 0.265195 | 0.524962 | 0.428830 | 0.794130 | -0.840106 | -0.840106 | -0.897785 | 1.255561 | 0.544188 | 3.178192 | -0.840106 | -0.109506 | -1.378443 | -1.359216 | -0.705522 | -0.205638 | 0.294246 | -0.282543 | -0.551711 | 1.005619 | 0.794130 | -0.301769 | -0.494032 | -0.013375 | 0.335763 | 0.817219 | 0.952026 | -0.973796 | -0.222726 | -0.742698 | 0.643895 | -0.184209 | 0.701669 | -0.819731 | -0.261242 | -1.301186 | -1.166379 | -0.761956 | 0.701669 | 0.374279 | -0.164951 | 0.104664 | 1.163867 | 1.876421 | -0.319017 | -0.588632 | -0.164951 | -0.683583 | -0.730373 | 1.413956 |
| 2 | FES | 0.326894 | 0.640167 | 1.204058 | -1.030623 | -0.341422 | -0.717350 | 0.326894 | -0.049034 | 0.828130 | -1.114162 | -0.383192 | -1.448320 | -1.364781 | -0.821774 | 1.579985 | 0.013621 | 0.264239 | 0.076275 | 1.642640 | 2.310956 | -0.466731 | -0.926198 | -0.550271 | 0.678069 | 1.136762 | 0.490421 | -0.864810 | -0.552064 | -0.531214 | 0.594670 | -0.239318 | 1.220161 | -0.906509 | -0.176769 | -1.427752 | -1.386052 | -0.948208 | 0.657219 | 0.261075 | -0.218469 | 0.010878 | 1.741404 | 1.762253 | -0.051671 | -0.739711 | -0.510365 | 0.176670 | 0.926839 | 1.551979 | -1.156963 | -0.677688 | -0.990259 | 0.343374 | -0.344280 | 0.989353 | -1.115287 | -0.761040 | -1.490371 | -1.490371 | -0.844392 | 0.864325 | 0.239184 | 0.489240 | -0.052548 | 1.677007 | 2.552204 | -0.094224 | -0.781878 | -0.010872 | 0.572592 | 1.218571 | 0.760134 | -1.115287 | -0.802716 | -1.094449 | 0.385050 | -0.219252 | 0.489240 | -1.136125 | -0.906907 | -1.532047 | -1.240315 | -0.948583 | 1.322761 | -0.302604 | 0.385050 | 0.155832 | 1.739521 | 2.677232 | 0.260022 | -0.531822 | -0.135900 | 0.051642 | 0.155832 | 0.906001 | -1.115287 | -0.969421 | -1.094449 | 1.260247 | 0.968515 | 2.177119 | -1.281991 | 0.009966 | -1.552885 | -1.302829 | -0.698526 | 0.093318 | -0.469308 | -0.031710 | 0.197508 | 1.656169 | 1.572817 | -0.406794 | -0.156738 | 0.030804 | -0.570568 | 1.728059 | 1.289230 | -1.030294 | -0.758638 | -1.155673 | 0.850401 | 0.139916 | 0.578745 | -1.134777 | -0.633258 | -1.531813 | -1.427329 | -0.758638 | -0.027256 | -0.779534 | 0.578745 | -0.215326 | 2.187784 | 3.190822 | 0.202606 | -0.654155 | -0.069050 | 0.374255 | 0.688411 | 0.876905 | -1.049918 | -0.966143 | -1.028975 | 0.876905 | 0.164818 | 1.337667 | -0.966143 | -0.149338 | -1.573511 | -1.091806 | -0.840481 | 0.269537 | -0.400663 | -0.275000 | 0.122931 | 2.007866 | 2.154472 | -0.086507 | -0.337831 | -0.107450 | 0.107815 | 0.696230 | 0.801304 | -1.005970 | -0.795822 | -1.090029 | 0.759274 | 0.465067 | 2.167266 | -0.816836 | -0.228422 | -1.510325 | -1.279162 | -0.816836 | 0.191874 | 0.170860 | -0.018274 | -0.396540 | 1.620881 | 1.536822 | -0.207407 | -0.459585 | 0.107815 | 0.257037 | 1.077542 | 1.308967 | -1.047357 | -0.479314 | -0.836971 | 1.014427 | -0.311005 | 1.266890 | -1.026318 | -0.332044 | -1.341897 | -1.236704 | -0.836971 | 1.035465 | 0.488462 | -0.058542 | -0.163735 | 1.014427 | 1.498315 | -0.226851 | -0.668662 | -0.395160 | -0.693206 | -0.720917 | 1.414123 |
| 3 | NTRK3 | 0.246599 | 0.825353 | 0.917953 | -1.211859 | -0.517355 | -0.563656 | 0.223449 | -0.054352 | 1.126304 | -1.165559 | -0.494205 | -1.535961 | -1.535961 | -0.957208 | 1.728208 | 0.570701 | 0.038248 | 0.246599 | 1.589307 | 2.191211 | -0.517355 | -0.702556 | -0.447905 | 0.611505 | 1.327439 | 1.050303 | -0.912740 | -0.866550 | -0.843456 | 0.519127 | -0.081333 | 1.581479 | -0.889645 | -0.196806 | -1.536294 | -1.443916 | -0.935834 | 0.565316 | 0.542222 | -0.150617 | -0.081333 | 1.281249 | 1.535290 | -0.081333 | -0.751077 | -0.242996 | 0.310085 | 1.071751 | 1.833417 | -1.236327 | -0.890115 | -1.005519 | 0.563974 | -0.174611 | 1.094832 | -1.213246 | -0.728550 | -1.559458 | -1.420973 | -0.705469 | 1.071751 | 0.310085 | 0.033116 | 0.263924 | 1.094832 | 1.833417 | 0.194681 | -0.497742 | -0.243853 | 0.308897 | 1.254642 | 1.162374 | -1.005920 | -1.075121 | -1.236590 | 0.124361 | 0.101294 | 0.839437 | -1.075121 | -0.567648 | -1.582594 | -1.328858 | -1.052054 | 1.139307 | -0.175510 | 0.101294 | 0.170495 | 1.900517 | 2.384923 | 0.147428 | -0.383112 | -0.152443 | -0.106309 | 0.908638 | 1.323843 | -1.052054 | -1.190456 | -1.236590 | 0.493432 | 0.124361 | 1.831316 | -1.490326 | -0.290844 | -1.651795 | -1.328858 | -0.798317 | 0.078227 | -0.360045 | -0.014041 | 0.908638 | 1.831316 | 1.393044 | 0.078227 | -0.198576 | 0.747169 | -0.797266 | 1.696953 | 1.073398 | -0.912740 | -1.236064 | -1.282254 | 1.881710 | 0.611505 | 1.581479 | -1.051307 | -0.081333 | -1.674862 | -1.490105 | -0.704888 | 0.218897 | -0.704888 | 0.057234 | -0.312279 | 1.004114 | 1.789331 | 0.126518 | -0.266090 | 0.472938 | 0.158406 | 0.947407 | 1.689996 | -0.909067 | -1.117920 | -1.117920 | 0.970613 | 0.088788 | 1.202672 | -1.001890 | -0.352125 | -1.628450 | -1.233950 | -1.071508 | 0.552906 | -0.143271 | -0.027242 | 0.042376 | 1.272290 | 1.922056 | 0.251229 | -0.398536 | -0.096859 | 0.396704 | 1.094985 | 1.327746 | -0.813649 | -0.860201 | -1.139513 | 1.164813 | 0.326876 | 2.538099 | -0.976581 | -0.441233 | -1.605034 | -1.418826 | -0.836925 | 0.303600 | 0.210496 | -0.278300 | -0.301576 | 1.118261 | 1.025157 | -0.045540 | -0.511061 | -0.278300 | 0.097329 | 1.216607 | 1.146652 | -1.045268 | -0.532265 | -1.138541 | 0.890151 | -0.112536 | 1.263243 | -0.695494 | -0.555584 | -1.558271 | -1.278451 | -0.882040 | 1.169970 | 0.237238 | -0.182491 | -0.019263 | 1.100015 | 1.636336 | -0.089218 | -0.578902 | -0.089218 | -0.648459 | -0.764176 | 1.412635 |
| 4 | ALK | -0.000966 | 0.532096 | 1.154002 | -1.222566 | -0.378551 | -0.600660 | 0.132300 | -0.200864 | 0.776416 | -1.067090 | -0.689504 | -1.378042 | -1.244777 | -0.689504 | 1.487166 | 0.665362 | 0.154511 | 0.265565 | 1.909173 | 2.442235 | -0.489606 | -0.889402 | -0.667293 | 0.169237 | 1.363510 | 0.899070 | -0.870223 | -0.450016 | -0.936572 | 0.301934 | -0.317319 | 1.518323 | -0.781759 | -0.427900 | -1.445244 | -1.401011 | -0.980804 | 0.832722 | 0.943303 | -0.206738 | -0.206738 | 1.341394 | 2.093344 | -0.074041 | -0.848107 | -0.516364 | 0.146070 | 0.764946 | 1.428027 | -1.135887 | -1.025373 | -0.936962 | 0.433405 | -0.318087 | 1.273308 | -1.157989 | -0.760141 | -1.467427 | -1.379016 | -0.738038 | 1.140692 | 0.344994 | 0.278686 | -0.052854 | 1.317513 | 2.908908 | 0.013454 | -0.804346 | -0.273881 | 0.299645 | 1.183215 | 0.763520 | -1.047799 | -0.893174 | -0.981531 | 0.078753 | -0.142140 | 0.454270 | -1.069888 | -0.848995 | -1.533762 | -1.312870 | -0.981531 | 1.337840 | -0.097961 | 0.388002 | 0.167110 | 2.110964 | 2.508570 | 0.189199 | -0.628103 | 0.056664 | 0.189199 | 0.608895 | 0.918144 | -1.224513 | -1.047799 | -1.246602 | 1.315751 | 0.896055 | 2.177232 | -1.379137 | -0.628103 | -1.555851 | -1.334959 | -1.025709 | -0.009604 | -0.407210 | -0.385121 | 0.233378 | 1.845893 | 1.912161 | -0.186318 | -0.274675 | 0.608895 | -0.870654 | 1.538540 | 1.229102 | -0.826449 | -1.069579 | -1.202195 | 1.405924 | 0.477611 | 1.162794 | -0.936962 | -0.384395 | -1.533735 | -1.312708 | -0.782243 | 0.322892 | -0.428600 | 0.300789 | -0.472806 | 1.052281 | 2.599470 | 0.168173 | -0.649627 | 0.212378 | 0.369469 | 0.657155 | 1.365304 | -0.869792 | -1.068959 | -1.179607 | 1.188266 | 0.192432 | 1.321044 | -0.847662 | -0.205902 | -1.467292 | -1.268125 | -0.936181 | 0.767803 | 0.280950 | -0.050994 | -0.006735 | 0.789932 | 1.520211 | -0.028865 | -0.515717 | -0.006735 | 0.171369 | 0.304228 | 0.525659 | -0.692214 | -0.825073 | -1.046505 | 1.832106 | 0.813520 | 2.673546 | -0.913646 | -0.227208 | -1.400795 | -1.201507 | -0.780787 | 0.259941 | 0.990666 | -0.426496 | -0.426496 | 0.459230 | 0.636375 | -0.249351 | -0.404353 | -0.072206 | 0.238907 | 0.615570 | 1.235957 | -0.979710 | -0.603047 | -0.979710 | 0.704197 | 0.194593 | 1.324584 | -0.891084 | -0.204227 | -1.312061 | -1.179120 | -0.846770 | 1.501837 | 0.571257 | -0.204227 | -0.115600 | 0.947920 | 1.058704 | -0.292853 | -0.514420 | -0.270697 | -0.688690 | -0.725365 | 1.414055 |
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| 385 | VRK2 | 0.913815 | 0.836508 | 0.449975 | 0.527282 | -0.158815 | -0.158815 | -0.158815 | -0.767604 | -0.777268 | -0.661308 | -0.158815 | 0.643242 | 0.382332 | 0.933142 | -0.129825 | 0.285698 | -0.458378 | -0.545348 | -0.187805 | -0.796594 | 0.053779 | 0.053779 | -0.120161 | 1.238276 | 1.354168 | 0.658818 | 0.687791 | -0.239341 | -0.239341 | -0.036531 | -0.722223 | -0.722223 | -0.239341 | -0.258657 | 0.320801 | 0.581557 | 0.204910 | -0.326260 | 0.233883 | -0.654619 | -0.490440 | -0.896060 | -0.490440 | -0.017216 | -0.017216 | 0.069703 | 1.617455 | 1.392879 | 0.416463 | 0.133302 | -0.061981 | -0.061981 | -0.315849 | -0.374434 | -0.335378 | -0.061981 | -0.120566 | 0.416463 | 0.367642 | 0.738680 | -0.638067 | 0.367642 | -0.647831 | -0.032689 | -1.028633 | -0.930992 | -0.393963 | -0.393963 | -0.052217 | 0.658854 | 3.601795 | 0.199955 | 0.170027 | -0.009542 | -0.009542 | -0.548250 | -0.857508 | 0.209931 | 1.087825 | 0.050314 | -0.209064 | -0.039471 | 0.409453 | -0.308824 | 0.499237 | -0.009542 | -0.029494 | -0.787676 | -0.977221 | -1.047054 | -1.047054 | -1.007149 | 0.689069 | -0.112765 | -0.201857 | -0.201857 | 0.223808 | 0.223808 | 1.391911 | 0.293102 | 0.986044 | 0.223808 | -0.686917 | 0.283203 | -0.597824 | 2.421426 | 0.372295 | 0.500985 | -0.370143 | -0.132563 | -1.102683 | -1.795625 | -0.865102 | -0.865102 | -0.677018 | 1.216846 | 0.411378 | -0.261544 | -0.740747 | -0.006649 | -0.006649 | 3.470116 | 1.675657 | -0.924271 | 0.340008 | -0.404285 | -0.006649 | 0.574511 | -0.648984 | -0.006649 | 3.694424 | 1.104692 | -1.148578 | -2.229333 | -1.739934 | -1.811305 | -1.811305 | -0.740747 | -1.547487 | 0.847371 | -0.244845 | 0.216091 | 0.105867 | 0.105867 | 0.616904 | 2.210136 | 2.160034 | 1.809323 | 1.568835 | 1.198083 | 1.969648 | 0.105867 | -0.254865 | -0.765902 | -0.545454 | -1.417223 | -2.028463 | -2.309032 | -1.657711 | -1.657711 | -0.485332 | -1.216215 | 1.073850 | 0.200009 | -0.231889 | -0.171624 | -0.171624 | -0.171624 | -0.342374 | -0.402639 | -0.543257 | 0.501334 | 0.742393 | 3.755636 | 1.857293 | -0.523169 | 2.389633 | -0.523169 | 0.491290 | -1.708378 | -1.979570 | -1.366877 | -1.366877 | -0.292154 | 0.050297 | 0.827835 | 0.296833 | -0.243651 | -0.243651 | -0.243651 | -0.613456 | -0.784135 | -0.471223 | -0.376401 | 0.097708 | 0.249422 | 1.671749 | 0.666638 | -0.746206 | -0.471223 | -0.651384 | -0.234169 | -0.243651 | -1.286690 | 0.306316 | 0.306316 | 2.136376 | -0.134920 | 1.286619 | -1.151698 |
| 386 | WNK4 | -0.787779 | -0.171271 | -0.107219 | -0.087202 | 0.056916 | 0.056916 | -0.167268 | 0.261085 | 0.409207 | 0.056916 | 0.589355 | 0.869586 | 0.689437 | 0.593358 | 0.713457 | 1.746308 | -0.759756 | -0.363430 | -1.112046 | -0.935901 | -0.543578 | -0.543578 | -0.463512 | -0.640355 | 0.075796 | -0.112449 | -0.186110 | -0.112449 | -0.112449 | -0.153372 | -0.096080 | -0.362079 | -0.042880 | -0.186110 | 0.464564 | 0.231304 | 0.640533 | 1.573576 | 3.001786 | -0.149280 | -0.177926 | -0.873616 | -0.783585 | -0.501217 | -0.501217 | -0.996385 | -0.076874 | 0.231143 | -0.080874 | -0.020871 | -0.076874 | -0.076874 | -0.008870 | -0.036872 | -0.192880 | 0.127138 | -0.504898 | 0.003131 | -0.596903 | 0.459156 | 1.595219 | 3.991352 | -0.520899 | -0.508898 | -1.348945 | -1.032927 | -0.360890 | -0.360890 | -0.600903 | 0.917850 | 4.265395 | 1.354307 | 0.234341 | -0.276232 | -0.276232 | 0.090227 | -0.440933 | -0.720925 | -0.552106 | -0.276232 | -0.259762 | -0.663279 | 1.465480 | 0.234341 | 1.959583 | -0.877390 | -0.778570 | -1.527959 | -1.527959 | -0.609751 | -0.609751 | -1.124442 | -1.161009 | 0.607030 | 0.511573 | 0.316508 | -0.231336 | -0.231336 | -0.281140 | -0.318492 | -0.231336 | 1.590658 | -0.343394 | 0.308207 | -0.708623 | 0.299906 | 1.794024 | 4.271769 | 0.059187 | -0.712773 | -1.563590 | -1.123656 | -1.181760 | -1.181760 | -0.488656 | -1.683890 | -0.145187 | -0.681278 | 1.008839 | 0.075796 | 0.075796 | 0.075796 | 0.628256 | 1.160254 | 2.449327 | 0.464564 | 0.988378 | 0.083981 | -0.308879 | -0.055157 | 2.228343 | 0.542318 | 0.010320 | -1.667521 | -1.671613 | -1.336045 | -1.336045 | -0.906354 | -1.487522 | 0.483187 | 0.129790 | 0.179681 | 0.125632 | 0.125632 | 0.558024 | 2.121287 | 0.765905 | 0.948840 | 0.125632 | 0.262833 | -0.186189 | 0.113159 | -0.132140 | 3.023489 | -0.988608 | -0.643526 | -0.872195 | -1.159070 | -1.271326 | -1.271326 | -0.951190 | -0.995206 | -0.404314 | -0.559371 | -0.035530 | 0.002186 | 0.002186 | -0.173824 | 0.002186 | 0.245248 | 0.291346 | 2.923121 | 1.334837 | 1.749719 | 1.058249 | 0.345826 | 0.743945 | -0.869484 | -0.563561 | -0.735381 | -0.986825 | -1.309510 | -1.309510 | -0.756335 | -0.567130 | -0.202433 | -0.153807 | 0.137950 | 0.044750 | 0.044750 | 0.044750 | 0.693100 | -0.072763 | 0.364873 | 0.826822 | 0.583691 | 0.891657 | 0.413499 | 0.802509 | 1.110475 | -0.660330 | -0.332103 | -0.976401 | -0.745426 | -0.794052 | -0.794052 | -0.660330 | 0.514442 | 0.883617 | -1.398059 |
| 387 | YANK2 | -0.069665 | 0.063579 | -0.005842 | -0.045031 | -0.069665 | -0.069665 | -0.234261 | -0.192832 | -0.205148 | -0.193951 | -0.101016 | 0.009834 | -0.162600 | 0.031108 | 0.167712 | 0.195704 | -0.139086 | -0.039433 | -0.010321 | -0.140206 | 0.381574 | 0.381574 | 0.447636 | -0.046635 | 0.037552 | -0.047674 | -0.123546 | -0.123546 | -0.123546 | -0.252425 | -0.315825 | -0.263858 | -0.165120 | -0.227481 | -0.167199 | -0.239953 | -0.123546 | -0.045596 | 0.085362 | -0.180710 | -0.118350 | -0.014415 | 0.254775 | 1.038440 | 1.038440 | 0.124857 | -0.313425 | -0.360362 | -0.326835 | -0.324824 | -0.360362 | -0.360362 | -0.395229 | -0.442165 | -0.415344 | -0.412662 | -0.421379 | -0.358350 | -0.462951 | -0.375113 | -0.303367 | 0.137165 | -0.422049 | -0.347622 | -0.112939 | -0.185355 | 3.159876 | 3.159876 | 0.243778 | -0.063168 | -0.323353 | -0.219643 | -0.047702 | -0.219643 | -0.219643 | -0.292422 | -0.306978 | 0.188830 | -0.074994 | 0.002334 | -0.047702 | -0.315166 | -0.066807 | -0.367931 | -0.172336 | -0.247845 | -0.172336 | -0.419786 | -0.226011 | 0.209755 | 0.209755 | 3.192793 | 0.301826 | 0.160395 | -0.064230 | -0.010748 | -0.064230 | -0.064230 | -0.304306 | -0.329264 | -0.101074 | 0.084331 | -0.137917 | 0.095028 | -0.275782 | -0.026199 | 0.204369 | 0.696406 | 0.003514 | -0.105828 | -0.330453 | -0.211604 | -0.002429 | -0.002429 | 0.484854 | -0.544935 | -0.456711 | -0.330677 | -0.021321 | -0.091213 | -0.091213 | 0.132211 | 0.566455 | 0.024509 | 0.729153 | 0.840292 | -0.043091 | -0.237870 | -0.190894 | -0.213809 | -0.086630 | -0.039653 | -0.351301 | -0.475043 | -0.091213 | 0.037113 | 0.037113 | 0.898726 | -0.678916 | -0.668713 | -0.626626 | -0.534799 | -0.553610 | -0.553610 | -0.575611 | -0.550741 | -0.575292 | -0.544045 | -0.532567 | -0.229665 | -0.458595 | -0.418102 | -0.569871 | -0.530335 | -0.557755 | -0.587089 | -0.553610 | -0.378884 | -0.293752 | -0.293752 | 11.265940 | -0.543125 | -0.506080 | -0.350320 | -0.270336 | -0.173513 | -0.173513 | -0.023648 | 0.010872 | -0.079216 | -0.137310 | -0.042170 | -0.103632 | -0.019438 | -0.168461 | -0.173513 | -0.197929 | -0.309907 | -0.392418 | -0.417676 | -0.351162 | 0.975736 | 0.975736 | 2.471022 | -0.168368 | -0.304390 | -0.333419 | -0.362448 | -0.297755 | -0.297755 | -0.356642 | -0.213156 | -0.322637 | -0.281167 | -0.355813 | -0.236379 | -0.165051 | -0.152610 | 0.179980 | 0.192421 | -0.297755 | -0.315172 | -0.456170 | -0.344201 | 0.189103 | 0.189103 | 4.510281 | 0.213252 | 1.104115 | -1.317366 |
| 388 | YANK3 | 0.036918 | 0.227998 | 0.064757 | 0.002751 | -0.064317 | -0.064317 | -0.118731 | -0.074440 | -0.044070 | -0.066848 | -0.065582 | -0.064317 | -0.044070 | -0.112403 | 0.026794 | 0.307720 | -0.174410 | -0.097218 | 0.128029 | -0.093422 | 0.122967 | 0.122967 | 0.043245 | 0.055050 | 0.259423 | 0.032073 | -0.042904 | -0.092486 | -0.092486 | -0.126346 | -0.177137 | -0.217045 | -0.085230 | -0.213417 | -0.165044 | -0.142067 | -0.210998 | -0.069509 | 0.225562 | -0.157788 | -0.092486 | 0.229190 | 0.130027 | 0.472261 | 0.472261 | 0.009096 | -0.236397 | -0.265901 | -0.285289 | -0.311421 | -0.355255 | -0.355255 | -0.350197 | -0.378015 | -0.371271 | -0.384759 | -0.450510 | -0.355255 | -0.407519 | -0.434494 | -0.282760 | 1.072728 | -0.359470 | -0.377172 | -0.279388 | -0.242298 | 2.736742 | 2.736742 | -0.063589 | 0.000460 | -0.119404 | -0.157008 | 0.082719 | -0.140556 | -0.140556 | -0.239268 | -0.219291 | 0.164979 | 0.021612 | -0.034794 | -0.124105 | -0.140556 | -0.135856 | -0.182861 | 0.967597 | -0.184037 | -0.172285 | -0.310951 | -0.200488 | 0.129725 | 0.129725 | 1.005201 | 0.546474 | 0.190063 | -0.171457 | -0.142075 | -0.116526 | -0.116526 | -0.167625 | -0.309422 | -0.145908 | 0.064873 | -0.199561 | -0.070538 | -0.249382 | -0.116526 | 0.100641 | 0.727873 | 0.055930 | 0.027826 | -0.148463 | -0.177844 | 0.054653 | 0.054653 | 0.308867 | -0.465117 | -0.361424 | -0.328094 | -0.112066 | -0.086143 | -0.086143 | 0.073101 | 0.637242 | -0.052813 | 0.532314 | 0.758217 | -0.086143 | -0.126879 | -0.326860 | -0.266372 | 0.017551 | 0.102727 | -0.281185 | -0.354017 | 0.055818 | -0.009607 | -0.009607 | 0.775500 | -0.689165 | -0.652955 | -0.644131 | -0.490467 | -0.609138 | -0.609138 | -0.609138 | -0.570190 | -0.540978 | -0.558322 | -0.536718 | -0.387315 | -0.317938 | -0.567451 | -0.651738 | -0.621005 | -0.626178 | -0.618875 | -0.630438 | -0.552237 | -0.278076 | -0.278076 | 12.039666 | -0.463843 | -0.388116 | -0.340672 | -0.189218 | -0.233925 | -0.233925 | -0.038677 | 0.055298 | -0.233925 | -0.247610 | -0.174620 | -0.121703 | -0.103455 | -0.165497 | -0.188306 | -0.091594 | -0.261296 | -0.305090 | -0.383554 | -0.240311 | 1.003254 | 1.003254 | 2.343530 | -0.131072 | -0.287017 | -0.247593 | -0.356229 | -0.247593 | -0.247593 | -0.343088 | -0.322937 | -0.325566 | -0.294902 | -0.371999 | -0.290522 | -0.211673 | -0.227443 | -0.141585 | -0.111798 | -0.200284 | -0.242336 | -0.308044 | 0.001219 | 0.300844 | 0.300844 | 4.306364 | 0.817024 | 0.591165 | -1.408189 |
| 389 | YSK4 | -0.032950 | 0.568875 | 0.640203 | 0.595623 | -0.015118 | -0.015118 | -0.371756 | -0.893337 | -0.746225 | -0.394045 | 0.158742 | -0.001744 | 0.689240 | 0.283565 | -0.336092 | -0.015118 | -0.532242 | 0.069583 | 0.408388 | -0.411877 | 0.457426 | 0.457426 | -0.563448 | 0.108431 | 0.381554 | 0.090522 | 0.242754 | 0.090522 | 0.090522 | -0.540794 | -0.831827 | -0.352743 | -0.124394 | 0.054702 | 0.099477 | 0.520354 | 0.126341 | -0.478111 | -0.334833 | -0.209465 | 0.229322 | 0.327825 | 0.211412 | 0.292006 | 0.292006 | -0.285581 | -0.156075 | 0.392044 | -0.111147 | 0.180883 | -0.111147 | -0.111147 | -1.077095 | -0.960282 | -0.758107 | -0.165061 | -0.241438 | 0.091028 | 0.531320 | 0.171898 | -0.358250 | -0.236945 | 0.082042 | 0.989583 | 1.187265 | 0.046100 | 0.203347 | 0.203347 | 0.207840 | -0.756930 | 0.055572 | 0.179110 | 0.117341 | -0.286534 | -0.286534 | -1.004006 | -1.118041 | -1.260585 | -0.381564 | 1.975165 | 3.410109 | 2.341028 | 1.077137 | -1.659709 | -1.322355 | -0.286534 | 0.340660 | 0.725529 | -0.300789 | -0.604883 | -0.604883 | -0.348303 | 0.278396 | -0.303281 | -0.345162 | -0.629020 | -0.098531 | -0.098531 | -0.991987 | -1.071095 | 0.422652 | 0.152753 | -0.396350 | 1.116011 | -0.373083 | 0.753044 | 0.064339 | -0.172986 | -0.098531 | 0.743737 | 1.441750 | -0.177639 | -0.610407 | -0.610407 | 1.004329 | -2.088449 | -1.134681 | -1.347178 | 0.244082 | -1.134681 | -1.134681 | 0.713553 | 2.270221 | 3.723111 | 1.869935 | 1.192908 | 1.894644 | 5.171060 | 0.229257 | -1.525083 | -1.416364 | -1.268110 | -1.164332 | -1.648628 | -1.554734 | -0.393410 | -0.393410 | -1.105030 | -0.860170 | -0.401302 | -0.802812 | -0.468220 | -0.774132 | -0.774132 | -0.195767 | -0.774132 | -1.132623 | -0.917529 | -0.974887 | -0.554258 | -0.783692 | 1.113919 | 3.594675 | 5.755180 | -0.057151 | 1.348133 | -0.812371 | -1.247340 | 0.535554 | 0.535554 | -1.352497 | 0.768778 | 0.442187 | -0.233993 | -0.169595 | -0.017799 | -0.017799 | -0.192594 | -0.670981 | -0.463987 | -0.500786 | -0.040799 | -0.017799 | 0.198394 | 0.290392 | 0.883775 | 0.529585 | -0.008600 | 0.635382 | -0.509985 | -0.606583 | 0.276592 | 0.276592 | -0.850376 | 0.963629 | 0.645691 | -0.036261 | -0.109986 | -0.036261 | -0.036261 | -0.626058 | -0.506256 | -0.460178 | -0.340375 | -0.552333 | -0.404884 | -0.192926 | 0.350793 | 1.074215 | 0.171089 | 0.737847 | 0.180305 | 0.019032 | -0.446354 | 0.244814 | 0.244814 | -0.884094 | 0.450034 | 0.936061 | -1.386095 |
390 rows × 211 columns
Extract kinase features
We will use two models, T5 and ESM2, to extract protein embeddings from the amino acid sequence for each kinase.
# load a df that contains sequence info
info = pd.read_excel('train_data/combine_info_PSPA.xlsx')Uncheck below to run to extract embeddings
For ESM2:
# # get esm embeddings from full kinase sequence
# feat = get_esm(info,'human_uniprot_sequence')
# import gc
# gc.collect()# # get esm embeddings from kinase domain sequence
# feat_kd = get_esm(info,'kinasecom_domain')
# gc.collect()For T5 model:
# # get T5 embeddings from full kinase sequence
# feat_t5 = get_t5(info,'human_uniprot_sequence')
# gc.collect()# # get T5 embeddings from kinase domain sequence
# feat_kd_t5 = get_t5(info,'kinasecom_domain')
# gc.collect()Save
# # for esm
# feat.astype(float).to_parquet('train_data/esm_combine.parquet')
# feat_kd.astype(float).to_parquet('train_data/esm_combine_kd.parquet')
# # for t5
# feat_t5.astype(float).to_parquet('train_data/t5_combine.parquet')
# feat_kd_t5.astype(float).to_parquet('train_data/t5_combine_kd.parquet')Or directly load the embeddings
# # for esm
feat= pd.read_parquet('train_data/esm_combine.parquet')
feat_kd = pd.read_parquet('train_data/esm_combine_kd.parquet')
# for t5
feat_t5 = pd.read_parquet('train_data/t5_combine.parquet')
feat_kd_t5 = pd.read_parquet('train_data/t5_combine_kd.parquet')ESM plot
sns.set(rc={"figure.dpi":300, 'savefig.dpi':300})
sns.set_context('notebook')
sns.set_style("ticks")ESM2 kinase colored by family
plot_cluster(feat,'umap',complexity=10,hue=info.group,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
To visualize PSPA categories, we only look at those with more than 10 kinases
cnt = info.pspa_category_big.str.split('_').str[0].value_counts()
cnt_10 = cnt[cnt>10]
cnt_10_bool = info.pspa_category_big.isin(cnt_10.index)
pspa_cat10 = info[cnt_10_bool].pspa_category_bigESM2 kinase colored by PSPA category
plot_cluster(feat,'umap',complexity=10,
hue=pspa_cat10,
legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
ESM2 kinase domain colored by family
plot_cluster(feat_kd,'umap',complexity=13,hue=info.group,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
ESM2 kinase domain colored by PSPA category
plot_cluster(feat_kd,'umap',complexity=13,hue=pspa_cat10,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
T5 plot
T5 kinase colored by family
plot_cluster(feat_t5,'umap',complexity=15,hue=info.group,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
T5 kinase colored by PSPA category
plot_cluster(feat_t5,'umap',complexity=15,hue=pspa_cat10,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
T5 kinase domain colored by family
plot_cluster(feat_kd_t5,'umap',complexity=13,hue=info.group,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
T5 kinase domain colored by PSPA category
plot_cluster(feat_kd_t5,'umap',complexity=13,hue=pspa_cat10,legend=True)/usr/local/lib/python3.9/dist-packages/umap/umap_.py:1945: UserWarning: n_jobs value 1 overridden to 1 by setting random_state. Use no seed for parallelism.
warn(f"n_jobs value {self.n_jobs} overridden to 1 by setting random_state. Use no seed for parallelism.")
Save Dataframes
target = {'combine': target}kinase_all = {'esm':feat,'t5':feat_t5, 'esm_kd':feat_kd, 't5_kd': feat_kd_t5}dfs = {}
for i, t in target.items():
for j, k in kinase_all.items():
# df = t.merge(k).reset_index(drop=True)
df = pd.concat([t,k],axis=1).set_index('kinase')
dfs[i+'_'+j] = df
# breakUncomment to save:
# for key, df in dfs.items():
# df.astype(float).to_parquet(f'train_data/{key}.parquet')