import pandas as pd,seaborn as sns
from katlas.core import *
from katlas.plot import *
from matplotlib import pyplot as plt
Overall Specificity
Load raw data
= pd.read_csv('raw/pspa_raw.csv').set_index('kinase')
pspa_ST
= pd.read_csv('raw/pspa_tyr_raw.csv').set_index('kinase') pspa_tyr
Map pspa tyr kinase
Transform protein name to gene name
= pd.read_csv('raw/lew_tyr_info.csv') pspa_info
pspa_info
lew_kinase | lew_kinase2 | kinase | tyr | kinase_tyr | |
---|---|---|---|---|---|
0 | ABL | ABL | ABL1 | NaN | ABL1 |
1 | ACK | ACK | TNK2 | NaN | TNK2 |
2 | ALK | ALK | ALK | NaN | ALK |
3 | ARG | ARG | ABL2 | NaN | ABL2 |
4 | AXL | AXL | AXL | NaN | AXL |
... | ... | ... | ... | ... | ... |
88 | VEGFR2 | VEGFR2 | KDR | NaN | KDR |
89 | VEGFR3 | VEGFR3 | FLT4 | NaN | FLT4 |
90 | WEE1_TYR | WEE1 | WEE1 | TYR | WEE1_TYR |
91 | YES | YES | YES1 | NaN | YES1 |
92 | ZAP70 | ZAP70 | ZAP70 | NaN | ZAP70 |
93 rows × 5 columns
= pspa_info.set_index('lew_kinase').kinase_tyr kinase_map
# map kinase name
= pspa_tyr.index.map(kinase_map) pspa_tyr.index
pspa_tyr.index
Index(['ABL1', 'TNK2', 'ALK', 'ABL2', 'AXL', 'BLK', 'BMPR2_TYR', 'PTK6', 'BTK',
'CSF1R', 'CSK', 'MATK', 'DDR1', 'DDR2', 'EGFR', 'EPHA1', 'EPHA2',
'EPHA3', 'EPHA4', 'EPHA5', 'EPHA6', 'EPHA7', 'EPHA8', 'EPHB1', 'EPHB2',
'EPHB3', 'EPHB4', 'BMX', 'PTK2', 'FER', 'FES', 'FGFR1', 'FGFR2',
'FGFR3', 'FGFR4', 'FGR', 'FLT3', 'FRK', 'FYN', 'HCK', 'ERBB2', 'ERBB4',
'IGF1R', 'INSR', 'INSRR', 'ITK', 'JAK1', 'JAK2', 'JAK3', 'KIT', 'LCK',
'LIMK1_TYR', 'LIMK2_TYR', 'LTK', 'LYN', 'MERTK', 'MET', 'MAP2K4_TYR',
'MAP2K6_TYR', 'MAP2K7_TYR', 'MST1R', 'MUSK', 'PKMYT1_TYR', 'NEK10_TYR',
'PDGFRA', 'PDGFRB', 'PDHK1_TYR', 'PDHK3_TYR', 'PDHK4_TYR', 'PINK1_TYR',
'PTK2B', 'RET', 'ROS1', 'SRC', 'SRMS', 'SYK', 'TEC', 'TESK1_TYR', 'TEK',
'TNK1', 'TNNI3K_TYR', 'NTRK1', 'NTRK2', 'NTRK3', 'TXK', 'TYK2', 'TYRO3',
'FLT1', 'KDR', 'FLT4', 'WEE1_TYR', 'YES1', 'ZAP70'],
dtype='object', name='kinase')
Combine
= pd.concat([pspa_ST,pspa_tyr]).iloc[:,:-23] # cut the 5 position of tyr as st do not have pspa_combine
pspa_combine
-5P | -5G | -5A | -5C | -5S | -5T | -5V | -5I | -5L | -5M | -5F | -5Y | -5W | -5H | -5K | -5R | -5Q | -5N | -5D | -5E | -5s | -5t | -5y | -4P | -4G | -4A | -4C | -4S | -4T | -4V | -4I | -4L | -4M | -4F | -4Y | -4W | -4H | -4K | -4R | -4Q | -4N | -4D | -4E | -4s | -4t | -4y | -3P | -3G | -3A | -3C | -3S | -3T | -3V | -3I | -3L | -3M | -3F | -3Y | -3W | -3H | -3K | -3R | -3Q | -3N | -3D | -3E | -3s | -3t | -3y | -2P | -2G | -2A | -2C | -2S | -2T | -2V | -2I | -2L | -2M | -2F | -2Y | -2W | -2H | -2K | -2R | -2Q | -2N | -2D | -2E | -2s | -2t | -2y | -1P | -1G | -1A | -1C | -1S | -1T | -1V | -1I | -1L | -1M | -1F | -1Y | -1W | -1H | -1K | -1R | -1Q | -1N | -1D | -1E | -1s | -1t | -1y | 1P | 1G | 1A | 1C | 1S | 1T | 1V | 1I | 1L | 1M | 1F | 1Y | 1W | 1H | 1K | 1R | 1Q | 1N | 1D | 1E | 1s | 1t | 1y | 2P | 2G | 2A | 2C | 2S | 2T | 2V | 2I | 2L | 2M | 2F | 2Y | 2W | 2H | 2K | 2R | 2Q | 2N | 2D | 2E | 2s | 2t | 2y | 3P | 3G | 3A | 3C | 3S | 3T | 3V | 3I | 3L | 3M | 3F | 3Y | 3W | 3H | 3K | 3R | 3Q | 3N | 3D | 3E | 3s | 3t | 3y | 4P | 4G | 4A | 4C | 4S | 4T | 4V | 4I | 4L | 4M | 4F | 4Y | 4W | 4H | 4K | 4R | 4Q | 4N | 4D | 4E | 4s | 4t | 4y | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
kinase | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AAK1 | 7.614134e+06 | 2.590563e+06 | 3.001315e+06 | 4.696631e+06 | 4.944312e+06 | 8.315838e+06 | 1.005654e+07 | 1.643306e+07 | 1.049974e+07 | 9.133578e+06 | 4.493054e+06 | 1.006273e+07 | 3.327455e+06 | 3.504743e+06 | 2.767294e+06 | 1.010574e+07 | 5.923673e+06 | 2.909153e+06 | 1.695156e+06 | 1.617849e+06 | 2.128670e+06 | 2.128670e+06 | 6.460995e+06 | 5.260313e+06 | 6.325834e+06 | 6.957994e+06 | 5.369435e+06 | 5.713921e+06 | 6.612202e+06 | 6.093662e+06 | 6.120309e+06 | 7.306988e+06 | 6.829678e+06 | 5.119222e+06 | 5.263236e+06 | 3.974771e+06 | 5.065008e+06 | 7.968511e+06 | 7.041049e+06 | 6.174444e+06 | 4.228327e+06 | 3.271231e+06 | 5.511934e+06 | 3.267818e+06 | 3.267818e+06 | 3.338570e+06 | 8.921287e+06 | 4.210323e+06 | 9.202468e+06 | 5.247518e+06 | 6.741480e+06 | 6.810878e+06 | 5271476.43 | 4928031.78 | 4.337562e+06 | 6.432257e+06 | 4.006022e+06 | 3.383022e+06 | 3.493591e+06 | 3.269350e+06 | 4.253144e+06 | 4.777087e+06 | 5.719014e+06 | 4.787112e+06 | 2.233865e+06 | 3.045337e+06 | 2.489664e+06 | 2.489664e+06 | 2.253600e+06 | 2.216029e+06 | 2.766177e+06 | 5.269960e+06 | 5.606488e+06 | 5.715777e+06 | 8.442377e+06 | 3330815.96 | 3699660.08 | 5.573758e+06 | 1.141874e+07 | 3289921.82 | 3.904724e+06 | 2.831768e+06 | 5.548345e+06 | 5.749699e+06 | 5.431821e+06 | 1.485362e+07 | 7.911792e+06 | 7.877661e+06 | 6.228872e+06 | 2.050311e+06 | 2.050311e+06 | 4.757609e+06 | 1.274357e+07 | 7922825.91 | 4.320089e+06 | 3.424102e+06 | 2951131.47 | 3.531424e+06 | 4.395649e+06 | 4.876362e+06 | 7.337788e+06 | 6213208.09 | 6.110447e+06 | 8.716737e+06 | 4935259.96 | 7.723412e+06 | 1.379149e+07 | 1.035962e+07 | 4.456719e+06 | 4.865705e+06 | 1.811253e+06 | 1.639403e+06 | 1.357999e+06 | 1.357999e+06 | 2.002371e+06 | 6415286.88 | 99964895.25 | 4.316875e+06 | 3.007075e+06 | 2745785.51 | 8.910120e+06 | 1.483692e+06 | 1.412341e+06 | 1.811600e+06 | 1.711245e+06 | 1.783236e+06 | 1.979521e+06 | 2.246919e+06 | 2.217612e+06 | 2.688448e+06 | 3.450818e+06 | 1.911930e+06 | 2358432.64 | 1421652.45 | 1.359588e+06 | 1.706013e+06 | 1.706013e+06 | 1.389642e+06 | 5119157.71 | 7278540.04 | 7.284322e+06 | 6.474715e+06 | 8.229141e+06 | 3.132517e+07 | 5.271194e+06 | 3.595811e+06 | 4.019474e+06 | 4.672000e+06 | 4.719446e+06 | 4.458959e+06 | 5.560394e+06 | 6.019748e+06 | 5.603859e+06 | 7.520621e+06 | 7.492737e+06 | 8.100332e+06 | 5364638.21 | 5087031.12 | 3.976345e+06 | 3.976345e+06 | 3.984759e+06 | 7.873215e+06 | 10666925.10 | 6726092.35 | 8.347111e+06 | 8474126.59 | 36243425.13 | 7.049439e+06 | 4.480458e+06 | 5.646461e+06 | 5.049205e+06 | 4.966940e+06 | 6.154423e+06 | 5.554385e+06 | 7784625.71 | 8536454.84 | 10411516.21 | 7199439.88 | 8496115.61 | 4678462.79 | 4293019.55 | 3871242.35 | 3871242.35 | 4144314.24 | 6.754641e+06 | 7.548893e+06 | 6.945442e+06 | 6.316584e+06 | 5.852228e+06 | 1.198637e+07 | 4.544765e+06 | 4.468426e+06 | 4.958371e+06 | 4.992757e+06 | 5.630292e+06 | 5.605199e+06 | 8.889243e+06 | 6.020663e+06 | 8.938081e+06 | 9.983402e+06 | 6.833482e+06 | 6.364453e+06 | 4.189046e+06 | 4921595.57 | 2705053.53 | 2705053.53 | 2909279.71 |
ACVR2A | 4.991039e+06 | 5.783856e+06 | 7.015771e+06 | 8.367603e+06 | 7.072052e+06 | 7.601400e+06 | 7.188292e+06 | 7.513916e+06 | 7.159895e+06 | 6.266123e+06 | 7.217726e+06 | 6.944710e+06 | 9.655464e+06 | 6.855045e+06 | 6.135260e+06 | 5.714942e+06 | 5.174360e+06 | 6.446238e+06 | 1.067680e+07 | 9.490371e+06 | 9.417512e+06 | 9.417512e+06 | 9.143263e+06 | 5.189501e+06 | 6.115977e+06 | 6.183207e+06 | 8.746775e+06 | 8.620216e+06 | 8.958569e+06 | 6.057960e+06 | 5.865980e+06 | 5.795429e+06 | 6.425254e+06 | 6.896824e+06 | 6.528270e+06 | 8.404648e+06 | 6.144456e+06 | 4.524121e+06 | 5.095303e+06 | 5.374812e+06 | 5.585577e+06 | 1.159205e+07 | 9.685649e+06 | 9.011965e+06 | 9.011965e+06 | 7.594632e+06 | 5.362571e+06 | 6.972104e+06 | 5.730145e+06 | 8.939563e+06 | 8.882397e+06 | 9.190427e+06 | 5827104.19 | 5369092.23 | 5.113058e+06 | 5.497993e+06 | 5.506587e+06 | 5.872247e+06 | 6.306875e+06 | 5.653091e+06 | 3.785783e+06 | 4.917763e+06 | 5.423081e+06 | 5.362812e+06 | 1.121296e+07 | 1.286189e+07 | 1.286491e+07 | 1.286491e+07 | 1.040912e+07 | 2.387566e+06 | 3.719260e+06 | 3.944903e+06 | 1.306509e+07 | 9.492139e+06 | 8.190708e+06 | 3735685.73 | 3374694.08 | 3.204388e+06 | 2.964892e+06 | 3752110.50 | 3.701144e+06 | 4.014811e+06 | 3.625178e+06 | 2.636457e+06 | 3.752367e+06 | 5.717786e+06 | 5.027611e+06 | 3.199105e+07 | 3.890473e+07 | 7.519771e+06 | 7.519771e+06 | 5.361107e+06 | 3.979857e+06 | 3356955.48 | 4.841646e+06 | 1.484390e+07 | 7884721.89 | 8.307355e+06 | 6.504731e+06 | 4.736171e+06 | 7.504066e+06 | 8479523.23 | 6.886560e+06 | 7.839785e+06 | 8170003.32 | 6.301557e+06 | 3.133306e+06 | 3.399144e+06 | 5.297926e+06 | 4.806449e+06 | 7.245964e+06 | 7.619248e+06 | 8.081957e+06 | 8.081957e+06 | 1.066555e+07 | 1962410.84 | 3317170.91 | 3.730968e+06 | 1.044143e+07 | 6905481.50 | 7.758918e+06 | 7.639850e+06 | 6.777724e+06 | 5.034766e+06 | 5.741319e+06 | 5.371632e+06 | 5.597504e+06 | 5.543419e+06 | 4.036400e+06 | 1.885554e+06 | 2.399467e+06 | 7.087499e+06 | 3680225.89 | 9707458.36 | 1.850553e+07 | 2.680623e+07 | 2.680623e+07 | 1.618774e+07 | 5866522.32 | 8056284.20 | 6.653384e+06 | 8.609148e+06 | 6.900910e+06 | 6.081477e+06 | 5.928764e+06 | 5.427121e+06 | 4.000029e+06 | 5.214510e+06 | 5.833633e+06 | 6.561916e+06 | 5.830996e+06 | 6.657870e+06 | 4.773873e+06 | 5.549060e+06 | 5.962668e+06 | 5.118947e+06 | 7342349.21 | 6089086.81 | 6.553063e+06 | 6.553063e+06 | 5.205000e+06 | 6.765402e+06 | 5981896.69 | 5346578.80 | 6.919984e+06 | 7959489.88 | 7230276.28 | 5.724909e+06 | 5.600558e+06 | 6.186548e+06 | 5.952585e+06 | 6.508513e+06 | 6.613615e+06 | 6.419485e+06 | 5958101.56 | 4666926.40 | 3909037.15 | 5041118.65 | 5297856.53 | 6281516.23 | 8795439.82 | 5241575.71 | 5241575.71 | 8237893.33 | 7.993594e+06 | 5.729649e+06 | 5.252570e+06 | 7.759900e+06 | 5.847330e+06 | 6.832130e+06 | 5.439640e+06 | 5.935277e+06 | 5.396841e+06 | 6.976825e+06 | 5.517910e+06 | 6.107147e+06 | 8.435954e+06 | 6.039473e+06 | 5.556301e+06 | 5.178735e+06 | 6.490098e+06 | 5.862481e+06 | 6.742906e+06 | 6750653.36 | 7414220.16 | 7414220.16 | 6209576.97 |
ACVR2B | 2.648033e+07 | 2.568969e+07 | 2.813730e+07 | 4.517591e+07 | 3.287672e+07 | 3.351696e+07 | 2.701119e+07 | 2.199626e+07 | 2.341299e+07 | 2.567058e+07 | 3.002968e+07 | 3.017269e+07 | 3.586173e+07 | 2.574340e+07 | 2.146662e+07 | 2.345728e+07 | 2.476593e+07 | 2.960038e+07 | 5.294219e+07 | 4.475642e+07 | 3.786952e+07 | 3.786952e+07 | 3.692942e+07 | 2.631562e+07 | 3.072667e+07 | 2.822669e+07 | 3.812676e+07 | 4.301345e+07 | 4.277259e+07 | 2.546188e+07 | 2.249653e+07 | 2.536736e+07 | 2.457962e+07 | 3.063236e+07 | 2.981163e+07 | 3.456903e+07 | 2.990129e+07 | 1.856668e+07 | 1.805841e+07 | 2.416071e+07 | 2.800391e+07 | 5.038351e+07 | 4.287344e+07 | 3.860183e+07 | 3.860183e+07 | 4.178142e+07 | 2.158990e+07 | 2.589693e+07 | 2.536640e+07 | 3.239116e+07 | 3.926870e+07 | 3.495329e+07 | 24544954.48 | 21195505.14 | 1.995029e+07 | 2.206874e+07 | 2.472332e+07 | 2.649370e+07 | 3.046722e+07 | 2.554031e+07 | 1.985960e+07 | 1.709886e+07 | 2.606574e+07 | 2.715736e+07 | 5.479210e+07 | 5.501460e+07 | 4.908985e+07 | 4.908985e+07 | 6.436937e+07 | 1.038309e+07 | 1.462589e+07 | 2.080868e+07 | 4.763634e+07 | 3.530416e+07 | 3.796242e+07 | 16548611.68 | 12258162.50 | 1.649462e+07 | 1.420021e+07 | 15925579.76 | 1.632044e+07 | 1.587850e+07 | 2.056051e+07 | 1.249803e+07 | 1.395433e+07 | 2.043374e+07 | 2.712993e+07 | 1.209644e+08 | 1.577022e+08 | 3.655727e+07 | 3.655727e+07 | 2.745861e+07 | 1.581925e+07 | 15139149.87 | 2.134236e+07 | 2.952187e+07 | 25664232.00 | 2.839195e+07 | 2.770178e+07 | 1.981812e+07 | 3.667232e+07 | 36335662.38 | 2.687820e+07 | 3.477983e+07 | 41496713.73 | 2.682559e+07 | 1.472776e+07 | 1.410475e+07 | 2.151356e+07 | 2.518703e+07 | 3.866288e+07 | 3.471438e+07 | 4.933006e+07 | 4.933006e+07 | 4.925704e+07 | 8904399.29 | 14948055.42 | 1.676565e+07 | 4.025226e+07 | 24215134.31 | 3.063690e+07 | 2.996006e+07 | 2.465090e+07 | 2.120177e+07 | 2.584864e+07 | 2.215540e+07 | 2.495283e+07 | 2.731012e+07 | 2.319200e+07 | 1.048079e+07 | 1.053792e+07 | 2.869759e+07 | 20916022.30 | 58048288.98 | 1.103872e+08 | 1.218935e+08 | 1.218935e+08 | 6.994578e+07 | 36115383.96 | 32738418.07 | 2.844781e+07 | 2.846730e+07 | 3.062024e+07 | 2.789244e+07 | 2.911362e+07 | 2.531559e+07 | 1.774232e+07 | 2.229611e+07 | 2.180289e+07 | 2.737951e+07 | 2.451023e+07 | 2.252698e+07 | 1.927138e+07 | 2.121534e+07 | 2.208222e+07 | 2.398039e+07 | 34155403.55 | 28198813.13 | 3.838533e+07 | 3.838533e+07 | 2.851153e+07 | 3.257098e+07 | 30150790.48 | 26899530.88 | 3.005933e+07 | 38558739.93 | 36859921.47 | 2.703936e+07 | 2.759019e+07 | 3.215902e+07 | 2.853096e+07 | 2.644059e+07 | 3.290203e+07 | 3.110638e+07 | 23931820.75 | 17025117.96 | 21234075.57 | 24959228.30 | 24492089.19 | 27379743.65 | 34799587.30 | 29745626.40 | 29745626.40 | 32930899.01 | 3.587234e+07 | 2.894266e+07 | 3.263029e+07 | 3.230768e+07 | 2.935148e+07 | 3.215859e+07 | 2.758575e+07 | 2.708777e+07 | 2.642711e+07 | 2.600846e+07 | 2.400660e+07 | 2.926031e+07 | 3.910546e+07 | 2.798420e+07 | 2.249692e+07 | 2.423690e+07 | 2.913286e+07 | 2.652739e+07 | 3.638873e+07 | 34729319.54 | 37906081.09 | 37906081.09 | 31761418.56 |
AKT1 | 1.839951e+07 | 1.810468e+07 | 1.683184e+07 | 1.724774e+07 | 2.264728e+07 | 1.780129e+07 | 1.303757e+07 | 1.327190e+07 | 1.415649e+07 | 1.540976e+07 | 1.667196e+07 | 1.574220e+07 | 1.602750e+07 | 1.990716e+07 | 2.896621e+07 | 4.630867e+07 | 1.498802e+07 | 1.425860e+07 | 1.146417e+07 | 1.146659e+07 | 1.298722e+07 | 1.298722e+07 | 1.306109e+07 | 1.939893e+07 | 2.204418e+07 | 1.906361e+07 | 1.679807e+07 | 2.456108e+07 | 2.105365e+07 | 1.613429e+07 | 1.406539e+07 | 1.598032e+07 | 1.917523e+07 | 1.565065e+07 | 1.672654e+07 | 2.071500e+07 | 2.172773e+07 | 3.938727e+07 | 5.864980e+07 | 1.939885e+07 | 1.714231e+07 | 1.209032e+07 | 1.498625e+07 | 1.635376e+07 | 1.635376e+07 | 1.475836e+07 | 1.350972e+07 | 1.207279e+07 | 1.448511e+07 | 1.314060e+07 | 2.006536e+07 | 1.566591e+07 | 6344537.74 | 6534731.06 | 7.876058e+06 | 7.508916e+06 | 7.223255e+06 | 9.468824e+06 | 9.373015e+06 | 2.230909e+07 | 6.216923e+07 | 2.418045e+08 | 1.493157e+07 | 8.856712e+06 | 4.399326e+06 | 4.368742e+06 | 8.590356e+06 | 8.590356e+06 | 7.963766e+06 | 6.789908e+06 | 1.326800e+07 | 2.111062e+07 | 2.197163e+07 | 4.133298e+07 | 4.051411e+07 | 9863410.69 | 9269011.71 | 2.289257e+07 | 1.116827e+07 | 11301067.87 | 8.789775e+06 | 7.431841e+06 | 1.878957e+07 | 4.890019e+07 | 1.630226e+08 | 1.222802e+07 | 9.955364e+06 | 3.198070e+06 | 2.965348e+06 | 7.792557e+06 | 7.792557e+06 | 6.120956e+06 | 2.229303e+07 | 28410424.95 | 1.584233e+07 | 1.487992e+07 | 24373755.69 | 1.811641e+07 | 9.634837e+06 | 7.220573e+06 | 2.097791e+07 | 24295340.44 | 1.785176e+07 | 2.661260e+07 | 14220032.24 | 2.526613e+07 | 3.818571e+07 | 3.752555e+07 | 2.168447e+07 | 3.081111e+07 | 1.557435e+07 | 8.290899e+06 | 6.467371e+06 | 6.467371e+06 | 1.930039e+07 | 7187402.87 | 13136588.59 | 9.834130e+06 | 1.866756e+07 | 25572492.56 | 2.454095e+07 | 2.793931e+07 | 3.395299e+07 | 2.444179e+07 | 3.378535e+07 | 4.623650e+07 | 1.704266e+07 | 2.246250e+07 | 1.581214e+07 | 1.705496e+07 | 1.902314e+07 | 2.157018e+07 | 18462014.12 | 5882718.69 | 5.841048e+06 | 9.088321e+06 | 9.088321e+06 | 1.147951e+07 | 14699453.43 | 21525508.02 | 1.821118e+07 | 2.359812e+07 | 6.103037e+07 | 4.038845e+07 | 2.217929e+07 | 2.044153e+07 | 2.271884e+07 | 1.580155e+07 | 1.524072e+07 | 1.832569e+07 | 1.667933e+07 | 3.135762e+07 | 2.609526e+07 | 3.910237e+07 | 1.812946e+07 | 2.170967e+07 | 10984748.38 | 7899072.12 | 9.884168e+06 | 9.884168e+06 | 1.295170e+07 | 1.977395e+07 | 28710820.58 | 19788527.29 | 2.465938e+07 | 38048939.96 | 28284495.88 | 1.855286e+07 | 1.989256e+07 | 1.959928e+07 | 1.991439e+07 | 2.452511e+07 | 2.324808e+07 | 2.285437e+07 | 30978724.22 | 37068344.22 | 45991399.36 | 22887074.13 | 25185236.76 | 11842652.96 | 12741276.18 | 13591360.01 | 13591360.01 | 13703183.16 | 4.100723e+07 | 2.647743e+07 | 2.171967e+07 | 2.020362e+07 | 3.896130e+07 | 3.227091e+07 | 1.836489e+07 | 1.691842e+07 | 2.057025e+07 | 2.022813e+07 | 1.732320e+07 | 1.551240e+07 | 2.315157e+07 | 2.951154e+07 | 5.094266e+07 | 4.815292e+07 | 3.269388e+07 | 2.889660e+07 | 1.970135e+07 | 13887460.52 | 17483074.60 | 17483074.60 | 11696833.54 |
AKT2 | 5.439238e+06 | 5.569477e+06 | 5.805463e+06 | 6.301076e+06 | 5.004932e+06 | 4.812023e+06 | 3.906822e+06 | 3.776845e+06 | 4.450345e+06 | 4.629320e+06 | 4.945258e+06 | 4.922328e+06 | 4.818865e+06 | 5.502850e+06 | 8.846468e+06 | 1.333189e+07 | 4.466206e+06 | 4.288906e+06 | 2.757477e+06 | 2.846855e+06 | 4.120974e+06 | 4.120974e+06 | 4.296410e+06 | 5.553405e+06 | 6.777167e+06 | 6.560099e+06 | 6.582762e+06 | 5.632446e+06 | 5.626769e+06 | 4.006943e+06 | 3.777457e+06 | 4.557922e+06 | 5.073876e+06 | 3.998927e+06 | 4.589151e+06 | 3.853566e+06 | 5.877348e+06 | 1.132398e+07 | 1.341026e+07 | 5.637101e+06 | 5.224016e+06 | 3.264182e+06 | 3.696234e+06 | 4.296297e+06 | 4.296297e+06 | 3.662821e+06 | 2.964034e+06 | 3.057508e+06 | 4.553668e+06 | 5.296786e+06 | 4.880460e+06 | 4.469909e+06 | 2397056.82 | 2383607.99 | 2.527122e+06 | 2.537479e+06 | 2.505547e+06 | 2.706595e+06 | 2.558155e+06 | 4.758159e+06 | 1.664300e+07 | 8.780359e+07 | 4.181480e+06 | 2.649826e+06 | 1.856813e+06 | 2.009072e+06 | 3.014999e+06 | 3.014999e+06 | 2.786490e+06 | 2.330602e+06 | 3.722199e+06 | 5.979231e+06 | 8.974567e+06 | 1.363241e+07 | 1.010563e+07 | 2942671.35 | 2646410.48 | 4.742427e+06 | 2.952549e+06 | 2697527.22 | 2.668971e+06 | 2.644657e+06 | 4.975136e+06 | 1.710828e+07 | 3.647206e+07 | 3.975190e+06 | 3.308858e+06 | 1.834547e+06 | 1.841426e+06 | 2.918462e+06 | 2.918462e+06 | 2.568866e+06 | 6.512287e+06 | 6714446.62 | 5.519547e+06 | 5.502392e+06 | 6214686.11 | 5.051604e+06 | 3.036099e+06 | 2.495300e+06 | 4.484786e+06 | 5714877.99 | 4.615614e+06 | 7.993743e+06 | 4279316.71 | 7.406520e+06 | 7.869915e+06 | 9.347586e+06 | 6.492965e+06 | 9.718326e+06 | 3.850429e+06 | 2.650874e+06 | 2.558032e+06 | 2.558032e+06 | 4.818770e+06 | 3390428.52 | 4010009.36 | 3.705137e+06 | 7.307115e+06 | 5708742.09 | 5.610131e+06 | 4.741528e+06 | 5.361541e+06 | 5.198120e+06 | 6.335042e+06 | 8.358214e+06 | 4.558845e+06 | 4.563970e+06 | 4.449433e+06 | 4.786098e+06 | 5.282519e+06 | 5.576834e+06 | 5150662.99 | 2286465.27 | 2.105027e+06 | 3.628510e+06 | 3.628510e+06 | 4.152546e+06 | 4557267.80 | 6705472.43 | 6.335118e+06 | 8.824775e+06 | 1.846957e+07 | 8.797708e+06 | 4.532827e+06 | 3.618750e+06 | 4.297882e+06 | 3.940765e+06 | 3.314978e+06 | 4.326879e+06 | 3.564338e+06 | 8.661598e+06 | 6.560407e+06 | 6.956136e+06 | 4.339532e+06 | 6.049277e+06 | 3175814.63 | 2833442.97 | 5.420414e+06 | 5.420414e+06 | 5.570731e+06 | 5.492324e+06 | 6803045.82 | 5712262.24 | 8.338449e+06 | 6916137.16 | 5765528.76 | 3.987390e+06 | 3.310626e+06 | 4.606345e+06 | 3.944711e+06 | 4.615744e+06 | 4.760317e+06 | 4.766437e+06 | 7463546.47 | 9581858.17 | 9777288.15 | 5173060.60 | 4932877.74 | 3157981.08 | 3133584.99 | 4337162.19 | 4337162.19 | 5399811.38 | 9.707178e+06 | 7.244547e+06 | 5.450861e+06 | 7.077129e+06 | 7.739123e+06 | 7.823933e+06 | 3.778465e+06 | 4.053743e+06 | 4.346510e+06 | 4.803778e+06 | 4.018213e+06 | 4.513237e+06 | 4.161649e+06 | 6.812202e+06 | 1.159068e+07 | 9.932526e+06 | 6.544477e+06 | 6.252361e+06 | 3.629092e+06 | 3510048.19 | 5499662.30 | 5499662.30 | 4188620.88 |
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KDR | 1.845994e+08 | 1.957994e+08 | 1.620357e+08 | 1.425970e+08 | 1.574334e+08 | 1.531566e+08 | 1.242434e+08 | 1.222766e+08 | 1.247404e+08 | 1.387319e+08 | 1.320501e+08 | 3.212094e+08 | 1.232232e+08 | 1.662514e+08 | 2.406540e+08 | 2.325982e+08 | 1.629513e+08 | 1.748919e+08 | 1.597018e+08 | 1.573808e+08 | 2.024139e+08 | 2.024139e+08 | 2.343784e+08 | 2.093327e+08 | 2.182291e+08 | 1.694768e+08 | 1.589847e+08 | 1.400628e+08 | 1.215501e+08 | 1.236381e+08 | 1.212599e+08 | 1.288776e+08 | 1.350534e+08 | 1.337981e+08 | 3.489371e+08 | 1.621376e+08 | 1.594608e+08 | 1.957685e+08 | 2.218688e+08 | 1.832141e+08 | 1.450143e+08 | 1.696696e+08 | 2.059610e+08 | 1.797783e+08 | 1.797783e+08 | 3.465001e+08 | 1.764191e+08 | 1.798238e+08 | 1.403922e+08 | 1.522956e+08 | 1.614405e+08 | 1.624723e+08 | 97116549.48 | 87894050.45 | 1.144018e+08 | 1.073124e+08 | 1.256586e+08 | 2.601954e+08 | 1.354943e+08 | 1.562289e+08 | 1.808831e+08 | 1.983757e+08 | 1.671430e+08 | 1.890440e+08 | 1.849732e+08 | 1.974620e+08 | 2.159131e+08 | 2.159131e+08 | 3.480707e+08 | 1.680516e+08 | 2.121389e+08 | 1.482204e+08 | 1.518226e+08 | 1.778658e+08 | 1.457419e+08 | 98964002.64 | 84868417.51 | 1.124117e+08 | 1.002724e+08 | 95951357.65 | 3.285036e+08 | 1.022371e+08 | 1.742936e+08 | 1.887219e+08 | 2.416173e+08 | 1.851435e+08 | 2.045934e+08 | 1.708671e+08 | 1.860065e+08 | 1.767469e+08 | 1.767469e+08 | 3.090243e+08 | 1.188183e+08 | 89051272.85 | 1.151995e+08 | 1.159393e+08 | 94696774.99 | 1.213877e+08 | 1.357540e+08 | 1.487129e+08 | 1.250131e+08 | 92272369.57 | 1.193200e+08 | 4.440216e+08 | 97288308.48 | 1.935258e+08 | 1.024152e+08 | 1.186661e+08 | 1.512899e+08 | 1.921856e+08 | 3.177159e+08 | 2.066806e+08 | 2.317617e+08 | 2.317617e+08 | 4.083211e+08 | 87256206.00 | 82746706.73 | 1.152023e+08 | 1.249391e+08 | 96370778.31 | 1.270050e+08 | 2.422357e+08 | 1.655861e+08 | 1.438567e+08 | 1.585119e+08 | 2.166335e+08 | 4.173761e+08 | 1.769612e+08 | 1.855242e+08 | 1.277513e+08 | 1.547331e+08 | 1.722054e+08 | 85832568.02 | 40667663.17 | 5.628033e+07 | 8.607198e+07 | 8.607198e+07 | 2.867590e+08 | 93375633.02 | 61857084.06 | 1.016017e+08 | 1.216673e+08 | 1.366118e+08 | 1.369927e+08 | 1.519612e+08 | 1.362806e+08 | 2.058174e+08 | 1.577987e+08 | 1.991776e+08 | 2.673724e+08 | 2.056605e+08 | 1.274456e+08 | 1.955392e+08 | 2.624548e+08 | 1.502404e+08 | 1.654458e+08 | 88813224.00 | 92015520.24 | 1.609418e+08 | 1.609418e+08 | 2.713942e+08 | 1.064620e+08 | 62825929.96 | 73448605.22 | 1.851681e+08 | 80953459.85 | 91255988.64 | 2.235464e+08 | 2.774836e+08 | 3.458329e+08 | 2.841824e+08 | 2.982122e+08 | 1.345363e+08 | 1.472108e+08 | 70781952.14 | 63438948.91 | 94692994.53 | 75925157.54 | 62880211.30 | 42400986.98 | 33264285.34 | 41583473.61 | 41583473.61 | 54785067.47 | 2.122488e+08 | 1.652770e+08 | 1.358981e+08 | 1.498572e+08 | 1.609743e+08 | 1.621507e+08 | 1.379373e+08 | 1.202268e+08 | 1.486198e+08 | 1.633846e+08 | 1.803211e+08 | 1.225866e+08 | 1.792355e+08 | 1.557999e+08 | 2.499706e+08 | 2.622000e+08 | 1.675666e+08 | 1.413788e+08 | 1.091009e+08 | 99767688.13 | 88619532.24 | 88619532.24 | 86228832.63 |
FLT4 | 9.527287e+07 | 1.108087e+08 | 1.018308e+08 | 1.047181e+08 | 1.068304e+08 | 9.834637e+07 | 9.014825e+07 | 1.040920e+08 | 9.891781e+07 | 1.105403e+08 | 1.302039e+08 | 2.535754e+08 | 1.431045e+08 | 1.469079e+08 | 1.256505e+08 | 1.432047e+08 | 1.242661e+08 | 1.257643e+08 | 1.202844e+08 | 1.108484e+08 | 1.137919e+08 | 1.137919e+08 | 1.233803e+08 | 1.006505e+08 | 1.063429e+08 | 1.073346e+08 | 1.102806e+08 | 9.273107e+07 | 8.137801e+07 | 9.285344e+07 | 8.773211e+07 | 1.020419e+08 | 9.208616e+07 | 1.250498e+08 | 2.314315e+08 | 1.770868e+08 | 1.185848e+08 | 1.091383e+08 | 1.257240e+08 | 1.192239e+08 | 9.857048e+07 | 1.158219e+08 | 1.273432e+08 | 1.135650e+08 | 1.135650e+08 | 1.419767e+08 | 8.383172e+07 | 9.303058e+07 | 8.376291e+07 | 1.088769e+08 | 1.142799e+08 | 1.054061e+08 | 74624848.46 | 77892681.57 | 8.858186e+07 | 8.942262e+07 | 1.088996e+08 | 1.685240e+08 | 1.075460e+08 | 1.210646e+08 | 1.010023e+08 | 1.139494e+08 | 1.166737e+08 | 1.294503e+08 | 1.362060e+08 | 1.405987e+08 | 1.184014e+08 | 1.184014e+08 | 1.448507e+08 | 9.920510e+07 | 9.956644e+07 | 9.223786e+07 | 1.008186e+08 | 1.135684e+08 | 9.434233e+07 | 80387170.27 | 86557385.12 | 9.314699e+07 | 1.009508e+08 | 78519178.46 | 2.038745e+08 | 9.396798e+07 | 1.220643e+08 | 9.664937e+07 | 1.225922e+08 | 1.216018e+08 | 1.264343e+08 | 1.309542e+08 | 1.367723e+08 | 1.017378e+08 | 1.017378e+08 | 1.303649e+08 | 5.552047e+07 | 46822983.26 | 6.073501e+07 | 7.467692e+07 | 62586752.98 | 7.544506e+07 | 8.490972e+07 | 9.952870e+07 | 7.105435e+07 | 62340565.83 | 1.038976e+08 | 3.415294e+08 | 67190188.21 | 1.180385e+08 | 4.183557e+07 | 4.828306e+07 | 1.092799e+08 | 1.522379e+08 | 2.699608e+08 | 1.840926e+08 | 1.395679e+08 | 1.395679e+08 | 3.009675e+08 | 48307484.74 | 29729503.87 | 5.531971e+07 | 7.234901e+07 | 50659803.65 | 7.615618e+07 | 1.794495e+08 | 1.433742e+08 | 8.980624e+07 | 8.620633e+07 | 1.853386e+08 | 3.033752e+08 | 1.509153e+08 | 9.156575e+07 | 5.443460e+07 | 6.212801e+07 | 1.054484e+08 | 45167113.31 | 31089503.64 | 3.793244e+07 | 6.239648e+07 | 6.239648e+07 | 2.123985e+08 | 45499258.91 | 32062870.69 | 5.067143e+07 | 7.470231e+07 | 6.613714e+07 | 8.649376e+07 | 9.429418e+07 | 9.823639e+07 | 1.313531e+08 | 1.030058e+08 | 1.522009e+08 | 2.170597e+08 | 2.515437e+08 | 1.011415e+08 | 8.351873e+07 | 1.260408e+08 | 8.660960e+07 | 8.692776e+07 | 62531758.10 | 81757111.18 | 1.324287e+08 | 1.324287e+08 | 2.862477e+08 | 5.387717e+07 | 65263004.12 | 43998774.09 | 8.973695e+07 | 46378007.47 | 65948151.74 | 1.282258e+08 | 1.664552e+08 | 1.924253e+08 | 1.811333e+08 | 2.825176e+08 | 9.225860e+07 | 1.189017e+08 | 54475523.79 | 36221303.85 | 50714552.25 | 54072557.92 | 35599201.38 | 38790459.40 | 33489880.18 | 47725114.43 | 47725114.43 | 59598202.96 | 1.211344e+08 | 1.045894e+08 | 7.782042e+07 | 9.473629e+07 | 9.558070e+07 | 8.808094e+07 | 7.800558e+07 | 7.513335e+07 | 8.895855e+07 | 1.017871e+08 | 1.115061e+08 | 9.370596e+07 | 1.353061e+08 | 1.383617e+08 | 1.209482e+08 | 1.419939e+08 | 1.131221e+08 | 9.016833e+07 | 9.482552e+07 | 92947714.00 | 83142327.88 | 83142327.88 | 93502673.43 |
WEE1_TYR | 4.876443e+06 | 5.871573e+06 | 5.126751e+06 | 4.908054e+06 | 3.972485e+06 | 3.994803e+06 | 5.210680e+06 | 5.241236e+06 | 5.842673e+06 | 5.156345e+06 | 5.821810e+06 | 8.696807e+06 | 7.004115e+06 | 3.886012e+06 | 5.605546e+06 | 5.857112e+06 | 4.488515e+06 | 4.444629e+06 | 4.879367e+06 | 4.494150e+06 | 5.391370e+06 | 5.391370e+06 | 6.383847e+06 | 5.814988e+06 | 7.229796e+06 | 5.408739e+06 | 6.297107e+06 | 3.957267e+06 | 4.032790e+06 | 5.299856e+06 | 7.055887e+06 | 6.131435e+06 | 5.706786e+06 | 6.592508e+06 | 1.075552e+07 | 6.892924e+06 | 4.726814e+06 | 5.759139e+06 | 8.598406e+06 | 5.518253e+06 | 4.362253e+06 | 4.957419e+06 | 7.124850e+06 | 5.238178e+06 | 5.238178e+06 | 7.799524e+06 | 4.311982e+06 | 4.544266e+06 | 3.512244e+06 | 3.772531e+06 | 3.971352e+06 | 3.798543e+06 | 4828316.91 | 5347044.88 | 4.762746e+06 | 4.560338e+06 | 5.405338e+06 | 7.004498e+06 | 5.238221e+06 | 3.217830e+06 | 4.738488e+06 | 5.190623e+06 | 2.973037e+06 | 3.512958e+06 | 3.636841e+06 | 3.875281e+06 | 5.588615e+06 | 5.588615e+06 | 7.562031e+06 | 4.466259e+06 | 8.208144e+06 | 4.720987e+06 | 5.154941e+06 | 9.448901e+06 | 6.486036e+06 | 4910417.32 | 5012522.04 | 4.603682e+06 | 3.938797e+06 | 4609456.85 | 8.109969e+06 | 4.767304e+06 | 4.520230e+06 | 5.516719e+06 | 8.177096e+06 | 3.896482e+06 | 5.313795e+06 | 3.152875e+06 | 3.945017e+06 | 5.966684e+06 | 5.966684e+06 | 7.340191e+06 | 2.549929e+06 | 2346751.23 | 2.437080e+06 | 3.414921e+06 | 2274245.53 | 2.153022e+06 | 3.751801e+06 | 3.882228e+06 | 5.446256e+06 | 4074361.02 | 7.610095e+06 | 1.013603e+07 | 3964860.83 | 3.526344e+06 | 3.148331e+06 | 3.302942e+06 | 1.908456e+06 | 4.904408e+06 | 2.097801e+06 | 1.581509e+06 | 2.931072e+06 | 2.931072e+06 | 2.440787e+07 | 2645011.91 | 4566742.82 | 2.807901e+06 | 3.480600e+06 | 2791747.97 | 2.905426e+06 | 3.622323e+06 | 4.436105e+06 | 3.603958e+06 | 3.944843e+06 | 4.409288e+06 | 1.175407e+07 | 3.995985e+06 | 3.266891e+06 | 6.350836e+06 | 1.847695e+07 | 4.035590e+06 | 4209748.11 | 1563572.88 | 1.967721e+06 | 4.312955e+06 | 4.312955e+06 | 4.701977e+06 | 2286548.56 | 2842024.50 | 2.801326e+06 | 3.496991e+06 | 3.865210e+06 | 3.116179e+06 | 3.750411e+06 | 4.155538e+06 | 3.767856e+06 | 4.125346e+06 | 5.289154e+06 | 6.063396e+06 | 5.469000e+06 | 2.733519e+06 | 7.570371e+06 | 9.469932e+06 | 3.413686e+06 | 3.487883e+06 | 1743381.33 | 1889036.23 | 3.091826e+06 | 3.091826e+06 | 4.187263e+06 | 3.285147e+06 | 4005935.68 | 2878185.59 | 4.897422e+06 | 3808906.86 | 3382221.05 | 4.799403e+06 | 6.171617e+06 | 4.162197e+06 | 4.760300e+06 | 5.001929e+06 | 6.524175e+06 | 4.625505e+06 | 4799746.41 | 11089123.17 | 17762952.56 | 3987265.34 | 3817935.02 | 2192702.44 | 2397048.38 | 3014291.42 | 3014291.42 | 3627261.67 | 3.218481e+06 | 3.911377e+06 | 3.442698e+06 | 4.108626e+06 | 4.145691e+06 | 3.674678e+06 | 3.186256e+06 | 3.315947e+06 | 3.193508e+06 | 4.717188e+06 | 3.464837e+06 | 4.113069e+06 | 5.223508e+06 | 3.936281e+06 | 8.499614e+06 | 9.559533e+06 | 4.159084e+06 | 3.232722e+06 | 2.564364e+06 | 2958838.67 | 2848258.50 | 2848258.50 | 3540779.21 |
YES1 | 4.388800e+07 | 3.701994e+07 | 3.481183e+07 | 3.092071e+07 | 3.417660e+07 | 3.269791e+07 | 2.818378e+07 | 2.430711e+07 | 2.589843e+07 | 3.001820e+07 | 3.098741e+07 | 7.225892e+07 | 2.717705e+07 | 3.656928e+07 | 4.411553e+07 | 4.190382e+07 | 3.952476e+07 | 4.870355e+07 | 4.847165e+07 | 3.954898e+07 | 4.223318e+07 | 4.223318e+07 | 4.330762e+07 | 3.871600e+07 | 4.307422e+07 | 3.249909e+07 | 2.954765e+07 | 2.915008e+07 | 2.504897e+07 | 2.950539e+07 | 2.581442e+07 | 3.276242e+07 | 3.278300e+07 | 2.518636e+07 | 6.846428e+07 | 2.626186e+07 | 3.509659e+07 | 3.405138e+07 | 3.474894e+07 | 3.761577e+07 | 3.466141e+07 | 4.874814e+07 | 5.422012e+07 | 3.696111e+07 | 3.696111e+07 | 4.370227e+07 | 3.430529e+07 | 3.527904e+07 | 2.773809e+07 | 3.129215e+07 | 3.653163e+07 | 2.911044e+07 | 18863566.65 | 18870762.51 | 2.231184e+07 | 2.498938e+07 | 2.680747e+07 | 9.774771e+07 | 3.305079e+07 | 3.487628e+07 | 2.354907e+07 | 2.568350e+07 | 3.872871e+07 | 4.690893e+07 | 5.742351e+07 | 7.298088e+07 | 3.822835e+07 | 3.822835e+07 | 4.001387e+07 | 4.153055e+07 | 3.516956e+07 | 3.125919e+07 | 3.022024e+07 | 4.150052e+07 | 3.066189e+07 | 20993603.39 | 17744895.01 | 2.151818e+07 | 2.303727e+07 | 18054015.23 | 4.098795e+07 | 2.184199e+07 | 4.026645e+07 | 2.763980e+07 | 3.009290e+07 | 3.726356e+07 | 4.439083e+07 | 4.266481e+07 | 4.454552e+07 | 3.470207e+07 | 3.470207e+07 | 3.822795e+07 | 2.962915e+07 | 12982072.83 | 1.331777e+07 | 1.301074e+07 | 11826901.63 | 3.448698e+07 | 5.152390e+07 | 7.122018e+07 | 3.906559e+07 | 22242818.10 | 1.488054e+07 | 3.592302e+07 | 17496588.38 | 1.673862e+07 | 1.068810e+07 | 9.109077e+06 | 1.190166e+07 | 1.057250e+07 | 1.462966e+07 | 1.871160e+07 | 2.442721e+07 | 2.442721e+07 | 1.840133e+07 | 12307440.08 | 75474764.65 | 4.227679e+07 | 2.417023e+07 | 30147674.19 | 2.885262e+07 | 2.375704e+07 | 1.568923e+07 | 1.585931e+07 | 2.961819e+07 | 1.925453e+07 | 3.061024e+07 | 4.110035e+07 | 2.131285e+07 | 1.114286e+07 | 1.432213e+07 | 2.389115e+07 | 17139000.66 | 21876801.89 | 3.521984e+07 | 3.219329e+07 | 3.219329e+07 | 5.872647e+07 | 20129956.79 | 20863777.95 | 2.984062e+07 | 2.479669e+07 | 3.613492e+07 | 4.003520e+07 | 3.617003e+07 | 3.200356e+07 | 2.996492e+07 | 3.308997e+07 | 3.008884e+07 | 4.279914e+07 | 2.266066e+07 | 1.973580e+07 | 2.003712e+07 | 2.643394e+07 | 2.790915e+07 | 2.198168e+07 | 17668186.60 | 35472597.75 | 3.687711e+07 | 3.687711e+07 | 3.447247e+07 | 1.489388e+07 | 19208725.20 | 17869773.24 | 2.081944e+07 | 19330414.01 | 26115657.86 | 3.933501e+07 | 4.381334e+07 | 4.191676e+07 | 2.900706e+07 | 8.135996e+07 | 7.895329e+07 | 4.802747e+07 | 28834890.52 | 15886947.68 | 26265507.49 | 17225935.88 | 18902690.14 | 14169689.03 | 15724328.22 | 14310277.23 | 14310277.23 | 18314094.58 | 2.295632e+07 | 2.948489e+07 | 2.440241e+07 | 3.538887e+07 | 2.743227e+07 | 2.953307e+07 | 2.461687e+07 | 2.378259e+07 | 2.531245e+07 | 3.765723e+07 | 3.625260e+07 | 3.659640e+07 | 3.258638e+07 | 3.278408e+07 | 3.088992e+07 | 3.984858e+07 | 3.431597e+07 | 2.627859e+07 | 2.217816e+07 | 25878925.56 | 19507805.80 | 19507805.80 | 24576787.03 |
ZAP70 | 3.479007e+07 | 5.089375e+07 | 3.604176e+07 | 3.698927e+07 | 2.720694e+07 | 2.970104e+07 | 2.687712e+07 | 2.196685e+07 | 1.775315e+07 | 3.041197e+07 | 2.771184e+07 | 5.883724e+07 | 2.006319e+07 | 3.704433e+07 | 2.720444e+07 | 2.613975e+07 | 2.844293e+07 | 4.062089e+07 | 5.030325e+07 | 4.489984e+07 | 9.376309e+07 | 9.376309e+07 | 6.983973e+07 | 5.147896e+07 | 4.173963e+07 | 4.557217e+07 | 3.782565e+07 | 2.568037e+07 | 1.934137e+07 | 1.978773e+07 | 1.643291e+07 | 1.671232e+07 | 1.810531e+07 | 1.446109e+07 | 4.825036e+07 | 1.829595e+07 | 2.499168e+07 | 1.782960e+07 | 2.003822e+07 | 3.011578e+07 | 2.407158e+07 | 4.895978e+07 | 7.337738e+07 | 7.543967e+07 | 7.543967e+07 | 8.880339e+07 | 2.702740e+07 | 2.804445e+07 | 2.469433e+07 | 3.448179e+07 | 3.465973e+07 | 2.465622e+07 | 17009918.51 | 15005688.07 | 1.426882e+07 | 1.379747e+07 | 1.575808e+07 | 5.686548e+07 | 1.819765e+07 | 2.163889e+07 | 1.628310e+07 | 1.819147e+07 | 2.574102e+07 | 3.899722e+07 | 5.211884e+07 | 5.347352e+07 | 1.147688e+08 | 1.147688e+08 | 1.099977e+08 | 1.965619e+07 | 3.622705e+07 | 2.090029e+07 | 3.062898e+07 | 3.239786e+07 | 2.937801e+07 | 16135929.72 | 9616165.56 | 1.081683e+07 | 1.473991e+07 | 11458833.09 | 4.740347e+07 | 1.080063e+07 | 2.330673e+07 | 1.464370e+07 | 1.340711e+07 | 3.392046e+07 | 3.543117e+07 | 3.510205e+07 | 5.104344e+07 | 9.830557e+07 | 9.830557e+07 | 8.429801e+07 | 1.020147e+07 | 12805905.03 | 1.714053e+07 | 2.463400e+07 | 15444852.89 | 1.793451e+07 | 1.374336e+07 | 1.642528e+07 | 1.368027e+07 | 11523548.37 | 9.936240e+06 | 5.806872e+07 | 9847734.79 | 1.624087e+07 | 8.526765e+06 | 6.874230e+06 | 1.644832e+07 | 2.055236e+07 | 5.827398e+07 | 3.356433e+07 | 1.131096e+08 | 1.131096e+08 | 2.805097e+08 | 5150115.57 | 7904296.55 | 1.747502e+07 | 2.553542e+07 | 16107605.30 | 2.143970e+07 | 2.570193e+07 | 1.262578e+07 | 1.250667e+07 | 1.593116e+07 | 2.456814e+07 | 5.006683e+07 | 3.373409e+07 | 2.179051e+07 | 9.079338e+06 | 7.361703e+06 | 2.302828e+07 | 10432974.78 | 9634651.04 | 2.115807e+07 | 2.880897e+07 | 2.880897e+07 | 2.435354e+08 | 19240725.01 | 10605012.03 | 1.599354e+07 | 1.659459e+07 | 1.679256e+07 | 2.107296e+07 | 1.927703e+07 | 1.410325e+07 | 1.849459e+07 | 1.611687e+07 | 2.337036e+07 | 3.643179e+07 | 5.260776e+07 | 1.506519e+07 | 1.580775e+07 | 1.500818e+07 | 2.219572e+07 | 1.973623e+07 | 14062208.30 | 21100501.01 | 4.264821e+07 | 4.264821e+07 | 5.097307e+07 | 5.028049e+07 | 16194823.09 | 18523719.84 | 2.481554e+07 | 20950947.73 | 15050336.77 | 2.979601e+07 | 2.144306e+07 | 1.839510e+07 | 3.816655e+07 | 1.778492e+07 | 3.066108e+07 | 3.039690e+07 | 18213790.50 | 7484113.68 | 8317140.76 | 12044214.04 | 9595410.26 | 8345465.51 | 5280276.61 | 6996614.41 | 6996614.41 | 9647949.46 | 2.827068e+07 | 1.811919e+07 | 1.410497e+07 | 1.926840e+07 | 1.675929e+07 | 1.523420e+07 | 1.446941e+07 | 8.742151e+06 | 1.219322e+07 | 1.591530e+07 | 1.128030e+07 | 1.073606e+07 | 1.547527e+07 | 1.927306e+07 | 1.613359e+07 | 1.601645e+07 | 2.046052e+07 | 1.166506e+07 | 1.714012e+07 | 16040747.79 | 12641195.81 | 12641195.81 | 9148528.89 |
396 rows × 207 columns
Scale each position to 1
= []
datafor kinase in pspa_combine.index:
= get_one_kinase(pspa_combine,kinase).T # It will drop s as it is a duplicate of t
m = m/m.sum()
norm
data.append(norm.unstack().values)
# Get column name
= norm.unstack().reset_index()
col 'Position'] = col['position'].astype(str) + col['aa']
col[
# Get the stacked normalize data
= pd.DataFrame(data,columns=col['Position'].tolist(),index=pspa_combine.index) norm
Check
Make sure it is one for each kinase
= get_one_kinase(norm,kinase,drop_s=False).T m
sum() m.
position
-5 1.0
-4 1.0
-3 1.0
-2 1.0
-1 1.0
1 1.0
2 1.0
3 1.0
4 1.0
dtype: float64
Get specificity score
= pd.DataFrame(norm.max(1),columns=['speci']).reset_index() speci
=Data.get_kinase_info().query('pseudo=="0"') info
= info[['kinase','group']] info
= speci.merge(info,how='left') speci
speci
kinase | speci | group | |
---|---|---|---|
0 | AAK1 | 0.639600 | Other |
1 | ACVR2A | 0.228739 | TKL |
2 | ACVR2B | 0.221615 | TKL |
3 | AKT1 | 0.466208 | AGC |
4 | AKT2 | 0.520962 | AGC |
... | ... | ... | ... |
391 | KDR | 0.124571 | TK |
392 | FLT4 | 0.145792 | TK |
393 | WEE1_TYR | 0.239644 | NaN |
394 | YES1 | 0.141651 | TK |
395 | ZAP70 | 0.378409 | TK |
396 rows × 3 columns
# unmapped are dual specific kinase with tyr tested
speci[speci.group.isna()]
kinase | speci | group | |
---|---|---|---|
309 | BMPR2_TYR | 0.134159 | NaN |
354 | LIMK1_TYR | 0.111245 | NaN |
355 | LIMK2_TYR | 0.094722 | NaN |
360 | MAP2K4_TYR | 0.090374 | NaN |
361 | MAP2K6_TYR | 0.078441 | NaN |
362 | MAP2K7_TYR | 0.096297 | NaN |
365 | PKMYT1_TYR | 0.091303 | NaN |
366 | NEK10_TYR | 0.154401 | NaN |
369 | PDHK1_TYR | 0.082651 | NaN |
370 | PDHK3_TYR | 0.079051 | NaN |
371 | PDHK4_TYR | 0.077827 | NaN |
372 | PINK1_TYR | 0.139151 | NaN |
380 | TESK1_TYR | 0.079315 | NaN |
383 | TNNI3K_TYR | 0.139203 | NaN |
393 | WEE1_TYR | 0.239644 | NaN |
= speci.group.fillna('Dual') speci.group
Plot
= speci.sort_values('speci',ascending=False)
sort_pspa sort_pspa
kinase | speci | group | |
---|---|---|---|
69 | CK1G3 | 0.819808 | CK1 |
63 | CK1A | 0.791040 | CK1 |
299 | YANK3 | 0.756693 | AGC |
110 | GSK3B | 0.744287 | CMGC |
298 | YANK2 | 0.739325 | AGC |
... | ... | ... | ... |
369 | PDHK1_TYR | 0.082651 | Dual |
380 | TESK1_TYR | 0.079315 | Dual |
370 | PDHK3_TYR | 0.079051 | Dual |
361 | MAP2K6_TYR | 0.078441 | Dual |
371 | PDHK4_TYR | 0.077827 | Dual |
396 rows × 3 columns
from fastcore.xtras import load_pickle
= load_pickle('raw/kinase_color.pkl') kinase_color
kinase_color
{'TK': (0.12156862745098039, 0.4666666666666667, 0.7058823529411765),
'AGC': (0.6823529411764706, 0.7803921568627451, 0.9098039215686274),
'CMGC': (1.0, 0.4980392156862745, 0.054901960784313725),
'Other': (1.0, 0.7333333333333333, 0.47058823529411764),
'TKL': (0.17254901960784313, 0.6274509803921569, 0.17254901960784313),
'STE': (0.596078431372549, 0.8745098039215686, 0.5411764705882353),
'CK1': (0.8392156862745098, 0.15294117647058825, 0.1568627450980392),
'CAMK': (1.0, 0.596078431372549, 0.5882352941176471),
'Atypical': (0.5803921568627451, 0.403921568627451, 0.7411764705882353),
'RGC': (0.7725490196078432, 0.6901960784313725, 0.8352941176470589)}
'Dual'] =(0.5, 0.5, 0.5) # add gray kinase_color[
set(rc={"figure.dpi":200, 'savefig.dpi':200})
sns.'notebook')
sns.set_context("ticks") sns.set_style(
='kinase',y='speci',hue='group',palette=kinase_color)
plot_rank(sort_pspa,x'Specificity based on PSPA')
plt.ylabel('Kinase'); plt.xlabel(
'speci','group',palette=kinase_color,figsize=(10,5))
plot_bar(sort_pspa,'Specificity'); plt.ylabel(
/home/zeus/miniconda3/envs/cloudspace/lib/python3.10/site-packages/katlas/plot.py:406: FutureWarning:
Passing `palette` without assigning `hue` is deprecated and will be removed in v0.14.0. Assign the `x` variable to `hue` and set `legend=False` for the same effect.
sns.barplot(data=df, x=group, y=value, order=idx, **kwargs)
plot for CDDM
= Data.get_cddm().iloc[:,:-6] ks
# ks = pd.read_excel('raw/freq_main.xlsx',index_col = 0)
= ks.max(1).reset_index(name='speci')
ks
= ks.rename(columns={'index':'kinase'})
ks
= ks.sort_values('speci',ascending=False).reset_index(drop=True)
sort_ks
# sort_ks.to_csv('raw/specificity_ks.csv',index=False)
=sort_ks.merge(info) sort_ks
='kinase',y='speci',hue='group',palette=kinase_color)
plot_rank(sort_ks,x'Specificity based on kinase-substrate dataset')
plt.ylabel('Kinase'); plt.xlabel(
'speci','group',palette=kinase_color,figsize=(10,5))
plot_bar(sort_ks,'Specificity'); plt.ylabel(
/home/zeus/miniconda3/envs/cloudspace/lib/python3.10/site-packages/katlas/plot.py:406: FutureWarning:
Passing `palette` without assigning `hue` is deprecated and will be removed in v0.14.0. Assign the `x` variable to `hue` and set `legend=False` for the same effect.
sns.barplot(data=df, x=group, y=value, order=idx, **kwargs)
= sort_ks[sort_ks.kinase.isin(sort_pspa.kinase)]
overlap
= overlap.rename(columns = {'speci':'ks_speci'})
overlap
= overlap.merge(sort_pspa.iloc[:,:2],'left')
overlap
= overlap.rename(columns = {'speci':'PSPA_speci'}) overlap
= overlap.query('ks_speci<0.5 & PSPA_speci>0.6')
upper_left
= overlap.query('ks_speci>0.8 & PSPA_speci<0.5') lower_right
=overlap.merge(info) overlap
from adjustText import adjust_text
=(7,5))
plt.figure(figsize=overlap.ks_speci, y = overlap.PSPA_speci)
plot_corr(x'Specificity based on PSPA')
plt.ylabel('Specificity based on kinase-substrate dataset')
plt.xlabel(# n = 20
= []
texts for i, row in upper_left.iterrows():
'ks_speci'], row['PSPA_speci'], row['kinase'], ha='center', va='bottom'))
texts.append(plt.text(row[
for i, row in lower_right.iterrows():
'ks_speci'], row['PSPA_speci'], row['kinase'], ha='center', va='bottom'))
texts.append(plt.text(row[
# Use adjustText to adjust text positions
=dict(arrowstyle='-', color='black'))
adjust_text(texts, arrowprops
plt.tight_layout()